拉曼光谱在口腔细菌鉴定中的应用  

Application of Raman spectroscopy in the identification of oral bacteria

作　　者：戚琳珑 秦子睿 滕健赢 张书旸 王媛 邓淑丽[1] QI Linlong;QIN Zirui;TENG Jianying;ZHANG Shuyang;WANG Yuan;DENG Shuli(Stomatology Hospital,School of Stomatology,Zhejiang University School of Medicine,Zhejiang Provincial Clinical Research Center for Oral Diseases,Key Laboratory of Oral Biomedical Research of Zhejiang Province,Cancer Center of Zhejiang University,Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province,Hangzhou 310000,China)

机构地区：[1]浙江大学医学院附属口腔医院·浙江大学口腔医学院·浙江省口腔疾病临床医学研究中心·浙江省口腔生物医学研究重点实验室·浙江大学癌症研究院·口腔生物材料与器械浙江省工程研究中心,浙江杭州310000

出　　处：《口腔医学》2024年第10期786-790,共5页Stomatology

基　　金：浙江省“尖兵”“领雁”研发攻关计划资助(2022C03060)。

摘　　要：口腔细菌与龋病、牙周病、口腔癌等多种口腔疾病相关,部分致病菌还在系统性疾病的发生发展中起重要作用,细菌病原体的快速鉴定有助于口腔疾病的诊断和精准治疗。拉曼光谱是一种简单、快速、无创的新型检测技术,可以提供大量详细的细菌信息,能快速鉴定细菌,但该技术在口腔临床中的应用目前较少,仍需进一步的探索。本文总结了拉曼光谱在鉴定口腔细菌中的研究进展,探讨了其临床应用的前景和挑战。Oral bacteria are associated with a variety of oral diseases such as caries,periodontal disease and oral cancer.Some pathogenic bacteria also play an important role in the occurrence and development of systemic diseases.The rapid identification of bacterial pathogens helps the diagnosis and precise treatment of oral diseases.Raman spectroscopy is a simple,rapid and non⁃invasive novel detection technique that can provide abundant and detailed bacterial information and can rapidly identify bacteria,but the application of this technique in oral clinical settings is still relatively rare and needs further exploration.This paper summarizes the research progress of Raman spectroscopy in the identification of oral bacteria and discusses the prospects and challenges of its clinical application.

关 键 词：拉曼光谱 口腔微生物群 口腔致病菌 

分 类 号：R780.2[医药卫生—口腔医学]