小檗碱、口腔菌群、系统性疾病三者相关性的研究进展  

Research progress of the relationship between berberine,oral microbiota and systemic diseases

作　　者：郭钒逸 王汝玉 杜一飞[1] 王羽立 周其冈[3] GUO Fanyi;WANG Ruyu;DU Yifei;WANG Yuli;ZHOU Qigang(Department of Oral and Maxillofacial Surgery,The Affiliated Stomatological Hospital of Nanjing Medical University,Jiangsu Province Key Laboratory of Oral Diseases,Jiangsu Province Engineering Research Center of Stomatological Translational Medicine,Nanjing 210029,China)

机构地区：[1]南京医科大学附属口腔医院口腔颌面外科,江苏省口腔疾病研究重点实验室,江苏省口腔转化医学工程研究中心,江苏南京210029 [2]四川省成都市崇州市人民医院口腔科,四川成都611230 [3]南京医科大学药学院,江苏南京211166

出　　处：《口腔医学》2024年第10期791-795,共5页Stomatology

基　　金：江苏省科教能力提升工程——江苏省研究型医院建设单位(YJXYYJSDW4);江苏省医学创新中心(CXZX202227)。

摘　　要：小檗碱具有抗菌、抗炎作用,是常用的传统中药之一。近年来多项研究证实小檗碱对心血管疾病、糖尿病、神经系统疾病等系统性疾病有较好的治疗效果,口腔菌群也与这些系统性疾病的发生发展存在密切联系。本文就小檗碱、口腔菌群、系统性疾病之间的相关性进行综述,为治疗系统性疾病提供新思路。Berberine is a commonly used traditional Chinese medicine,which has the antimicrobial and anti⁃inflammatory properties.Ongoing investigations have identified berberine as an effective medicine for systemic diseases,such as cardiovascular diseases,diabetes mellitus and neurological disorders.At the same time,there exists a close relationship between oral microbiota and these systemic diseases.This review focuses on the relationship between berberine,oral microbiota and systemic diseases,offering new insights for the treatment of systemic diseases.

关 键 词：小檗碱 口腔菌群 系统性疾病 

分 类 号：R78[医药卫生—口腔医学]