Bypassing PELO-mediated ATPase activation of the NLR is a common pathogenic cause of NLR-associated autoinflammatory diseases  

作　　者：Xiurong Wu Zhang-Hua Yang Yue Zheng Jianfeng Wu Jiahuai Han 

机构地区：[1]State Key Laboratory of Cellular Stress Biology,School of Life Sciences,Faculty of Medicine and Life Sciences,Xiamen University,Xiamen,Fujian,361102,China [2]Zhejiang Provincial Key Laboratory of Pancreatic Disease,MOE Joint International Research Laboratory of Pancreatic Diseases,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,310012,China [3]Research Unit of Cellular Stress of CAMS,Xiang’an Hospital of Xiamen University,Cancer Research Center of Xiamen University,School of Medicine,Faculty of Medicine and Life Sciences,Xiamen University,Xiamen,Fujian,361102,China [4]Department of Gastroenterology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou,310012,China [5]Laboratory Animal Center,Xiamen University,Xiamen,Fujian,361102,China

出　　处：《Cellular & Molecular Immunology》2024年第6期634-637,共4页中国免疫学杂志（英文版）

基　　金：National Natural Science Foundation of China(82388201 to JH,32170751 to Z-HY);Fundamental Research Funds for the Central Universities(226-2024-00015 to XW);National Key R&D Program of China(2020YFA0803500 to JH);CAMS Innovation Fund for Medical Science(2019-I2M-5-062 to JH);Fujian Province Central to Local Science and Technology Development Special Program(No.2022L3079 to JH);Fu-Xia-Quan Zi-Chuang District Cooperation Program(No.3502ZCQXT2022003 to JH).

摘　　要：Nucleotide-binding and oligomerization domain(NOD)-like receptors(NLRs)are evolutionarily conserved intracellular pattern recognition receptors(PRRs)that sense microbial and danger signals,trigger immediate host defenses,and prime the adaptive immune response for long-lasting protection[1].In humans,22 known NLRs exist,and mutations in NLR family genes are associated with a wide range of inflammatory and autoimmune conditions,including hereditary periodic fever syndromes,Crohn’s disease,Blau’s syndrome,infantile enterocolitis,multiple sclerosis,and asthma[2,3].

关 键 词：NLR INFLAMMATORY BYPASS 

分 类 号：R593[医药卫生—内科学]