细菌多重耐药基因lsa(E)的研究进展  

Research progress on multidrug resistance gene lsa(E)in bacteria

作　　者：李琼[1] 刘伟成 张博 陈峥[1] 金钢铸 胡紫微 许春燕 LI Qiong;LIU Weicheng;ZHANG Bo;CHEN Zheng;JIN Gangzhu;HU Ziwei;XU Chunyan(College of Veterinary Medicine,Henan Agricultural University,Zhengzhou 450046,China)

机构地区：[1]河南农业大学动物医学院,河南郑州450046

出　　处：《生物技术》2024年第5期641-646,共6页Biotechnology

基　　金：中国博士后科学基金项目(2021M690924)

摘　　要：目前,携带lsa(E)基因的菌株可对林可酰胺类、截短侧耳素类、链阳菌素A类三大类常用抗菌药物耐药,使细菌产生多重耐药抗性。该文阐述了多重耐药基因lsa(E)的发现、作用机制、遗传环境以及其在不同环境中的流行状况,旨为畜牧业合理使用抗生素、新药物的开发和遏制lsa(E)耐药基因传播提供参考。The resistance gene lsa(E)encodes an ABC transport protein,which mediates drug efflux pumps,thereby reducing the intracellular drug concentration in bacteria and leading to drug resistance.Strains carrying the lsa(E)gene have shown resistance to the three major classes of antibiotics-lincoamides,pleulopleutin and streptomycin A,resulting in multidrug resistance.This review aims to comprehensively summarize the discovery,mechanism of action,genetic environment,and prevalence of the multidrug resistance gene lsa(E)in different environment.The information gathered will provide reference for the rational use of antibiotics in livestock farming,the development of novel drugs,and the containment of the spread of lsa(E)resistance genes.

关 键 词：lsa(E)基因 多重耐药 耐药机制 基因遗传环境 基因簇 流行传播 可移动遗传元件 抗生素 

分 类 号：Q784[生物学—分子生物学]