m^(6)A修饰介导的氧化应激与DNA损伤在衰老中的研究进展  

Research advances in m^(6)A-mediated oxidative stress and DNA damage in aging

作　　者：方镜 张雷[1] FANG Jing;ZHANG Lei(College of Life Science and Health Engineering,Hubei University of Technology,Wuhan 430068,China)

机构地区：[1]湖北工业大学生命科学与健康工程学院,湖北武汉430068

出　　处：《生物技术》2024年第5期647-651,670,共6页Biotechnology

摘　　要：N6-甲基腺嘌呤(m^(6)A)是一种动态且可逆的表观转录组学调控,在各种生物过程中发挥着关键作用。近年来,m^(6)A修饰在衰老及衰老相关过程中参与调控机制引起了越来越多的关注,这为了解衰老分子机制并发展新的治疗策略成为一种可能。该文重点介绍m^(6)A修饰介导调控氧化应激与DNA损伤诱导衰老的潜在机制,并总结了m^(6)A在衰老及相关过程中潜在的治疗方向。最后讨论了衰老过程中m^(6)A表观转录组学调控认识的局限性以及技术困难,强调了未来研究的潜在方向。m^(6)A is a dynamic and reversible epitranscriptomic regulation that plays a crucial role in various biological processes.In recent years,the involvement of m^(6)A modification in the regulation mechanisms of aging and aging-related processes has attracted increasing attention,offering a possibility to understand the molecular mechanisms of aging and develop new therapeutic strategies.This article focuses on the potential mechanisms by which m^(6)A modification mediates the regulation of oxidative stress and DNA damage-induced aging,and summarizes the potential therapeutic directions of m^(6)A in aging and related processes.Finally,the limitations and technical challenges in understanding the epitranscriptomic regulation of m^(6)A in aging processes are discussed,emphasizing the potential directions for future research.

关 键 词：N6-甲基腺苷 衰老 氧化应激 DNA损伤 甲基化酶 去甲基化酶 阅读蛋白 

分 类 号：R394.3[医药卫生—医学遗传学]