乳腺癌术后多发转移介入治疗的疗效分析  

Analysis of curative effect of interventional therapy for postoperative multiple metastases of breast cancer

作　　者：刘迪 周军[1] 丁勋[1] 朱扬 杨福刚 何思成 龙清云[1] 卢伟 LIU Di;ZHOU Jun;DING Xun;ZHU Yang;YANG Fugang;HE Sicheng;LONG Qingyun;LU Wei(Interventional Diagnostic and Therapeutic Center,Zhongnan Hospital of Wuhan University,Wuhan 430071,China)

机构地区：[1]武汉大学中南医院介入诊疗中心,湖北武汉430071

出　　处：《实用放射学杂志》2024年第10期1695-1698,共4页Journal of Practical Radiology

摘　　要：目的探讨介入治疗对乳腺癌术后多发转移的治疗效果。方法对15例乳腺癌术后多发转移患者进行介入治疗。经综合评估后,所有患者实施化疗栓塞治疗,方案为载药微球(DEB)加载多西他赛,联合卡铂,1 d 1次,共21 d,治疗2次,后更改方案为多西他赛+卡铂,联合普通栓塞微球治疗,1 d 1次,共21 d,治疗4次,每2个周期及介入治疗后1、3、6个月行CT/MRI检查,评价其疗效,同时记录不良反应。结果治疗后3个月总缓解率(ORR)为75%,疾病控制率(DCR)为91.7%;治疗后6个月ORR为50%,DCR为83.3%;常见不良反应大部分在Ⅲ级以下。结论乳腺癌术后多发转移的介入治疗近期疗效确切,毒副作用小,在乳腺癌术后转移综合治疗中值得进一步推广。Objective To investigate the curative effect of interventional therapy on postoperative multiple metastases of breast cancer.Methods A total of 15 patients with multiple metastases after breast cancer surgery were treated with interventional therapy.After comprehensive evaluation,all patients were treated with chemoembolization.The therapeutic regimen was docetaxel loaded on drug-eluting bead(DEB)combined with carboplatin,once in 1 d for 21 d,2 times in total,and then the regimen was changed to docetaxel and carboplatin combined with ordinary embolization microspheres,once in 1 d for 21 d,4 times in total.CT/MRI was performed on every 2 cycles and 1,3,and 6 months after interventional therapy to evaluate its efficacy and record adverse reactions.Results The overall remission rate(ORR)at 3 months after treatment was 75%,and the disease control rate(DCR)was 91.7%.The ORR and DCR at 6 months after treatment were 50%and 83.3%,respectively.Most of the common adverse reactions were below gradeⅢ.Conclusion Interventional therapy for multiple metastases of breast cancer after operation has a definite short-term effect,with little adverse reactions.It is worthy of further promotion in the comprehensive treatment of postoperative metastases of breast cancer.

关 键 词：乳腺癌 介入治疗 载药微球 化疗栓塞 

分 类 号：R737.9[医药卫生—肿瘤] R815[医药卫生—临床医学]