甲状腺癌组织GATA3蛋白表达及其与临床病理特征、手术预后的关系分析  

Expression of GATA3 Protein in Thyroid Carcinoma and Its Relationship with Clinicopathologic Features and Surgical Prognosis

作　　者：薛翠娥 王鑫磊 王亚红 XUE Cui’e;WANG Xinlei;WANG Yahong(Department of Pathology,Xilingol League Central Hospital,Xilinhot,Inner Mongolia Autonomous Region,026000,China)

机构地区：[1]内蒙古锡林郭勒盟中心医院病理科,内蒙古自治区锡林浩特市026000

出　　处：《医学分子生物学杂志》2024年第6期591-596,共6页Journal of Medical Molecular Biology

基　　金：锡林郭勒盟科技计划(No.20210405)。

摘　　要：目的分析甲状腺癌组织GATA结合蛋白3(GATA binding protein 3,GATA3)蛋白表达情况及其与临床病理特征和手术预后的关系。方法选取内蒙古锡林郭勒盟中心医院2016年8月~2017年12月收治的150例采用手术治疗的甲状腺癌患者,取癌组织与切缘正常组织采用免疫组化法检测GATA3蛋白表达,比较癌组织和切缘正常组织的GATA3蛋白表达量。比较不同临床病理特征患者甲状腺癌组织GATA3蛋白表达量;随访5年分析癌组织GATA3蛋白表达与手术预后的关系。结果甲状腺癌组织GATA3蛋白表达量低于切缘正常组织(P<0.05);未分化癌和髓样癌、TNM分期Ⅲ~Ⅳ期、多发病灶、最大肿瘤直径≥2 cm、有淋巴结转移患者癌组织GATA3蛋白表达量分别低于乳头状腺癌和滤泡状腺癌、TNM分期Ⅰ~Ⅱ期、单发病灶、最大肿瘤直径<2 cm、无淋巴结转移患者(P<0.05);随访期间甲状腺癌患者生存率为83.45%、死亡率为16.55%;未分化癌(RR=1.772,95%CI:1.221~2.571)、髓样癌(RR=2.423,95%CI:1.609~3.650)、TNM分期Ⅲ~Ⅳ期(RR=2.020,95%CI:1.447~2.818)、多发病灶(RR=1.914,95%CI:1.421~2.578)、最大肿瘤直径≥2 cm(RR=1.818,95%CI:1.129~2.928)、有淋巴结转移(RR=1.937,95%CI:1.241~3.022)、GATA3蛋白表达量(RR=0.488,95%CI:0.333~0.715)均为甲状腺癌患者死亡的影响因素(P<0.05);甲状腺癌组织GATA3蛋白高表达患者生存率高于GATA3蛋白低表达患者(P<0.05)。结论GATA3蛋白在甲状腺癌组织中呈低表达,且GATA3蛋白表达与病理类型、TNM分期、病灶数目、肿瘤大小及淋巴结转移情况有关,上述指标均是患者手术预后的影响因素。Objective To analyze the expression of GATA binding protein 3(GATA3)in thyroid carcinoma and its relationship with clinicopathological features and surgical prognosis.Methods A total of 150 patients with thyroid carcinoma treated by surgery in Xilingol League Central Hospital,Inner Mongolia from August 2016 to December 2017 were selected,and the expression level of GATA3 protein was detected by immunohistochemistry between the cancer tissues and the normal tissues at the cutting edge.The expression level of GATA3 protein was compared between the cancer tissues and the normal tissues at the cutting edge,and the expression level of GATA3 protein in the thyroid carcinoma tissues of patients with different clinical and pathological characteristics was also compared.The relationship between the expression level of GATA3 protein in cancer tissues and the surgical prognosis was analyzed after 5 years follow-up.Results The expression level of GATA3 protein in the thyroid carcinoma tissues was lower than that in the normal tissues(P<0.05).The expression level of GATA3 protein was lower in the thyroid carcinoma tissues of undifferentiated and medullary carcinoma,TNM stageⅢ-Ⅳ,multiple lesions,maximum tumor diameter≥2 cm,and patients with lymph node metastasis than in the thyroid carcinoma tissues of papillary adenocarcinoma and follicular adenocarcinoma,TNM stageⅠ-Ⅱ,single lesion,maximum tumor diameter<2 cm,and patients without lymph node metastasis(P<0.05).During the follow-up period,the survival rate of thyroid cancer patients was 83.45%,and the mortality rate was 16.55%.Undifferentiated carcinoma(RR=1.772,95%CI:1.221-2.571),medullary carcinoma(RR=2.423,95%CI:1.609-3.650),TNM stageⅢ-Ⅳ(RR=2.020,95%CI:1.447-2.818),multiple lesions(RR=1.914,95%CI:1.421-2.578),maximum tumor diameter≥2 cm(RR=1.818,95%CI:1.129-2.928),lymph node metastasis(RR=1.937,95%CI:1.241-3.022),GATA3 protein expression(RR=0.488,95%CI:0.333-0.715)were all factors affecting the death of thyroid carcinoma patients(P<0.05).The survival rate of

关 键 词：甲状腺癌 GATA结合蛋白3 临床病理特征 手术预后 

分 类 号：R736.1[医药卫生—肿瘤]