Merits and demerits of administering esketamine in preventing postpartum depression following cesarean section  

作　　者：Takahiko Nagamine 

机构地区：[1]Department of Psychiatric Internal Medicine,Sunlight Brain Research Center,Hofu 7470066,Yamaguchi,Japan

出　　处：《World Journal of Clinical Cases》2024年第36期6883-6886,共4页世界临床病例杂志（英文）

摘　　要：Emergency cesarean section is associated with the development of postpartum depression.Esketamine has been demonstrated to have a rapid onset of antide-pressant effects.Randomized controlled trials and meta-analyses have demon-strated the efficacy of esketamine in preventing postpartum depression after ce-ssarean section.However,the data included in these analyses were derived from elective cesarean sections and differed in the dose and timing of esketamine ad-ministration.Esketamine is a dissociative anesthetic with a dose-dependent risk of inducing psychotic symptoms,including hallucinations.In the setting of cesarean section,esketamine should be administered with caution and only if the potential benefits outweigh the risks.

关 键 词：Esketamine Cesarean section DEPRESSION Adverse event Medial prefrontal cortex 

分 类 号：R749.4[医药卫生—神经病学与精神病学]