Role of high-dose amoxicillin dual therapy for Helicobacter pylori eradication in an Irish cohort:A prospective study  

作　　者：Raffaele Palmirotta Concetta Cafiero Marica Colella 

机构地区：[1]Interdisciplinary Department of Medicine,University of Bari“Aldo Moro”,Bari 70124,Italy [2]Area of Molecular Pathology,Anatomic Pathology Unit,Fabrizio Spaziani Hospital,Frosinone 03100,Italy

出　　处：《World Journal of Clinical Cases》2024年第35期6859-6863,共5页世界临床病例杂志（英文）

摘　　要：Helicobacter pylori(H.pylori)infections may cause chronic gastritis,peptic ulcer disease,gastric cancers,and other conditions outside of the gastrointestinal tract.Hence,it is important to diagnose and treat it early.H.pylori is resistant to certain drugs in traditional eradication therapy,so alternative therapy protocols are needed,such as high-dose amoxicillin dual therapy(HDADT).This article aims to comment on a recent paper by Costigan et al in the World Journal of Clinical Cases.In this study,the authors recruited 139 patients diagnosed with H.pylori,all treated with HDADT.Of these,93 were treatment-naïve and 46 had received at least one alternative treatment in the past.Four weeks after the end of the treatment,the urea breath test was administered to estimate the eradication rate.The total eradication rate was 56%(78/139),62%for the treatment-naïve arm and 43%for the previous treatment arm,thus indicating a lower success rate for the arm that had previously received a different treatment regimen.In conclusion,a therapeutic approach with first-line HDADT may potentially be a better treat-ment,but the results are not sufficient to recommend the use of this regimen in a country with high levels of dual resistance.

关 键 词：Helicobacter pylori Helicobacter pylori eradication High dose amoxicillin High dose amoxicillin dual therapy Triple therapy 

分 类 号：R573[医药卫生—消化系统]