Facing stress and inflammation:From the cell to the planet  

作　　者：Jean-Marc Cavaillon Irshad H Chaudry 

机构地区：[1]Department of Global Health,Institut Pasteur,Paris 75015,France [2]Department of Surgery,University of Alabama Birmingham,Birmingham,AL 35294,United States

出　　处：《World Journal of Experimental Medicine》2024年第4期53-85,共33页世界实验医学杂志（英文）

摘　　要：As identified in 1936 by Hans Selye,stress is shaping diseases through the induction of inflammation.But inflammation display some yin yang properties.On one hand inflammation is merging with the innate immune response aimed to fight infectious or sterile insults,on the other hand inflammation favors chronic physical or psychological disorders.Nature has equipped the cells,the organs,and the individuals with mediators and mechanisms that allow them to deal with stress,and even a good stress(eustress)has been associated with homeostasis.Likewise,societies and the planet are exposed to stressful settings,but wars and global warming suggest that the regulatory mechanisms are poorly efficient.In this review we list some inducers of the physiological stress,psychologic stress,societal stress,and planetary stress,and mention some of the great number of parameters which affect and modulate the response to stress and render it different from an individual to another,from the cellular level to the societal one.The cell,the organ,the individual,the society,and the planet share many stressors of which the consequences are extremely interconnected ending in the domino effect and the butterfly effect.

关 键 词：Climate change CYTOKINES Genetic diversity Global health Immunity Microplastics RESILIENCE Yin yang 

分 类 号：R364.5[医药卫生—病理学]