Perspectives on the extracellular matrix in inflammatory bowel disease and bowel decellularization protocols  

作　　者：Caroline Bures de Paulo Maria Angelica Miglino Patricia Castelucci 

机构地区：[1]Department of Surgery,School of Veterinary Medicine and Animal Sciences,University of São Paulo,São Paulo 05508-270,São Paulo,Brazil [2]Laboratório de Medicina Regenerativa,Universidade de Marilia,Marilia 00000,São Paulo,Brazil [3]Department of Anatomy,University of São Paulo,São Paulo 05508-000,Brazil

出　　处：《World Journal of Experimental Medicine》2024年第4期86-95,共10页世界实验医学杂志（英文）

基　　金：Supported by São Paulo Research Foundation(Fundação de AmparoàPesquisa do Estado de São Paulo-FAPESP,Brazil),No.2014/25927-2,No.2018/07862-1,No.2021/05445-7,and No.2022/00086-1;the Brazilian National Council for Scientific and Technological Development(Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq,Brazil);and the Brazilian Federal Agency for Support and Evaluation of Graduate Education(Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-CAPES,Brazil).

摘　　要：The extracellular matrix(ECM)is a non-cellular three-dimensional structure present in all tissues that is essential for the intestinal maintenance,function and structure,as well as for providing physical support for tissue integrity and elasticity.ECM enables the regulation of various processes involved in tissue homeostasis,being vital for healing,growth,migration and cell differentiation.Structurally,ECM is composed of water,polysaccharides and proteins,such as collagen fibers and proteoglycans,which are specifically arranged for each tissue.In pathological scenarios,such as inflammatory bowel disease(IBD),the deposition and remodeling of the ECM can be altered in relation to the homeostatic composition.IBD,such as Ulcerative colitis and Crohn’s disease,can be differentiated according to ECM alterations,such as circulating levels of collagen,laminin and vimentin neoepitopes.In this context,ECM presents parti-cularities in both physiological and pathological processes,however,exploring methods of tissue decellularization is emerging as a promising frontier for new therapeutic interventions and clinical protocols,promoting the development of new approaches to intestinal diseases.

关 键 词：Extracellular matrix Inflammatory bowel disease Decellularization protocols Regenerative medicine INTESTINE 

分 类 号：R574[医药卫生—消化系统]