Sepsis-associated liver injury:Mechanisms and potential therapeutic targets  

作　　者：Jia-Wen Chen Chen-Yi Liu Shu Li Shi-Wen Wu Chao Cai Ming-Qin Lu 

机构地区：[1]Department of Infectious Diseases,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang Province,China

出　　处：《World Journal of Gastroenterology》2024年第42期4518-4522,共5页世界胃肠病学杂志（英文）

基　　金：The Zhejiang Medical and Health Science and Technology Program,China,No.2021KY205 and No.2024KY139;The Wenzhou Science and Technology Plan Project,China,No.Y2023111.

摘　　要：In this editorial,we examined a recent article in the World Journal of Gastroenterology that focused on sepsis-associated liver injury(SLI)and its treatment.SLI is a serious complication of sepsis,primarily caused by microcirculatory disturbances,the gut-liver axis,and inflammatory responses.Specific treatment recommendations for SLI are lacking.The gut-liver axis represents a potential therapeutic target,with metformin showing promise in modulating the gut microbiome and enhancing intestinal barrier function.Although immunomodulatory therapies are being explored,anti-tumor necrosis factor agents and interleukin-1 receptor antagonists have not demonstrated significant clinical benefits.Statins may reduce liver inflammation and prevent injury in sepsis,but their clinical application is limited.Reduced D-related human leucocyte antigen expression on monocytes and lymphocytes suggests immune suppression in patients,indicating that corticosteroids could reverse clinical deterioration in severe infections and address adrenal cortical insufficiency.Current large-scale studies on glucocorticoid therapy for sepsis have yielded mixed results,likely due to inadequate assessment of the immune status of the host.Future research should prioritize the development of personalized immunotherapy tailored to patients’immune profiles,focusing on identifying novel indicators of immune status and advancing immunomodulatory targets and therapeutics for septic patients.

关 键 词：Sepsis Sepsis-associated liver injury Gut-liver axis Immunosuppression Inflammation Immune dysregulation Glucocorticoid Adrenal cortical insufficiency 

分 类 号：R575[医药卫生—消化系统]