Esophageal melanosis:Two case reports and review of literature  

作　　者：Liubou Kazacheuskaya Kshitij Arora 

机构地区：[1]Department of Pathology,Louisiana State University Health,Shreveport,LA 71103,United States

出　　处：《World Journal of Gastroenterology》2024年第42期4557-4565,共9页世界胃肠病学杂志（英文）

摘　　要：Esophageal melanosis(EM)is a rare condition characterized by melanin pigmentation in the esophageal mucosa.It is not well understood and has been documented in less than 100 cases worldwide.CASE SUMMARY We report two cases of African American patients who complained of significant weight loss(over 20 pounds in approximately six months)and abdominal pain during their first visit.The first case involves a 54-year female with a history of hepatic steatosis and polysubstance abuse,who also experiences nausea and vomiting.The second case is a 59-year-old male with hypertension and gastroesophageal reflux disease(GERD),who was diagnosed with esophageal squamous cell carcinoma.Both cases show benign melanocytes in the basal layer on the esophagus biopsy and are diagnosed as EM.CONCLUSION It is important to note that EM has been associated with malignancies such as carcinoma and melanoma.Therefore,accurate diagnosis and appropriate management are crucial.Patients with EM,especially those with concurrent risk factors(e.g.,GERD,smoking),should be carefully monitored for any signs of malignancy.

关 键 词：ESOPHAGUS Melanoblasts Esophageal melanosis Gastroesophageal reflux disease Case report 

分 类 号：R571[医药卫生—消化系统]