Risk factors for hemocoagulase-associated hypofibrinogenemia in patients with gastrointestinal bleeding  

作　　者：Fei Zou Mian-Tao Wu Yong-Yi Wang 

机构地区：[1]Department of Oncology,The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College/Chongqing Key Laboratory of Prevention and Treatment for Occupational Diseases and Poisoning,Chongqing 400060,China [2]Department of Laboratory Medicine,State Key Laboratory of Oncology in South China,Guangdong Provincial Clinical Research Center for Cancer,Sun Yat-sen University Cancer Center,Guangzhou 510060,Guangdong Province,China [3]Department of Occupational Disease and Poisoning,The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College/Chongqing Key Laboratory of Prevention and Treatment for Occupational Diseases and Poisoning,Chongqing 400060,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第11期3437-3444,共8页世界胃肠外科杂志（英文）

基　　金：Supported by The First Batch of Key Discipline on Public Health in Chongqing.

摘　　要：BACKGROUND With the widespread use of hemocoagulase in patients with gastrointestinal bleeding,clinicians have become increasingly concerned about coagulation dis-orders associated with this medication.Risk factors for hypofibrinogenemia asso-ciated with hemocoagulase are poorly understood.AIM To determine risk factors for hemocoagulase-associated hypofibrinogenemia in patients with gastrointestinal bleeding.METHODS We performed a retrospective analysis of the medical documentation of hospit-alized patients treated with hemocoagulase for gastrointestinal bleeding.Hypofib-rinogenemia was defined as a decrease in plasma fibrinogen concentration to less than 2.0 g/L.The included patients were divided into two groups:acquired hypofibrinogenemia group and non-hypofibrinogenemia group.We used logistic regression analysis to identify potential risk factors and established risk assess-RESULTS There were 36 patients in the acquired hypofibrinogenemia group and 73 patients in the non-hypofibrinogenemia group.The hypofibrinogenemia group showed higher rates of intensive care unit admissions(P=0.021),more female patients(P=0.005),higher in-hospital mortality(P=0.027),larger hemocoagulase doses(P=0.026),more Packed Red Cells transfusions(P=0.024),and lower baseline fibrinogen levels(P<0.000).Binary logistic regression was employed to examine the risk factors associated with acquired hypofibrinogenemia.The analysis revealed that baseline fibrinogen[odds ratio(OR)0.252,95%CI:0.137-0.464,P<0.000],total hemocoagulase doses(OR 1.074,95%CI:1.015-1.137,P=0.014),and female gender(OR 2.856,95%CI:1.015–8.037,P=0.047)were statist-ically significant risk factors.CONCLUSION Higher doses of total hemocoagulase,female gender,and a lower baseline fibrinogen level were risk factors for hemocoagulase-associated hypofibrinogenemia in patients with gastrointestinal bleeding.

关 键 词：HEMOCOAGULASE Gastrointestinal bleeding HYPOFIBRINOGENEMIA Risk factors Snake venom 

分 类 号：R573.2[医药卫生—消化系统]