Clinical study of different interventional treatments for primary hepatocellular carcinoma based on propensity-score matching  

作　　者：Xiao-Bo Cheng Li Yang Ming-Qian Lu Yi-Bo Peng Lei Wang Shuang-Ming Zhu Zhi-Wei Hu Zhong-Liang Wang Qin Yang 

机构地区：[1]Department of Oncology,Dangyang People’s Hospital,Dangyang 444100,Hubei Province,China [2]Department of Oncology,Yichang Central People’s Hospital(The First Clinical Medical School of China Three Gorges University),Yichang 443008,Hubei Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第11期3463-3470,共8页世界胃肠外科杂志（英文）

摘　　要：BACKGROUND Transcatheter arterial chemoembolization(TACE)is the main treatment for patients with primary hepatocellular carcinoma(PHC)who miss the opportunity to undergo surgery.Conventional TACE(c-TACE)uses iodized oil as an embolic agent,which is easily washed by blood and affects its efficacy.Drug-eluting bead TACE(DEB-TACE)can sustainably release chemotherapeutic drugs and has a long embolization time.However,the clinical characteristics of patients before the two types of interventional therapies may differ,possibly affecting the conclusion.Only a few studies have compared these two interventions using propensity-score matching(PSM).AIM To analyze the clinical effects of DEB-TACE and c-TACE on patients with PHC based on PSM.METHODS Patients with PHC admitted to Dangyang People’s Hospital(March 2020 to March 2024)were retrospectively enrolled and categorized into groups A(DEB-TACE,n=125)and B(c-TACE,n=106).Sex,age,Child-Pugh grade,tumor-node-meta-stasis stage,and Eastern Cooperative Oncology Group score were selected for 1:1 PSM.Eighty-six patients each were included post-matching.Clinical efficacy,liver function indices(aspartate aminotransferase,alanine aminotransferase,total bilirubin,and albumin),tumor serum markers,and adverse reactions were compared between the groups.RESULTS The objective response and disease control rates were significantly higher in group A(80.23%and 97.67%,respectively)than in group B(60.47%and 87.21%,respectively)(P<0.05).Post-treatment levels of aspartate aminotransferase,alanine aminotransferase,and total bilirubin were lower in group A than in group B(P<0.05),whereas post-treatment levels of albumin in group A were comparable to those in group B(P>0.05).Post-treatment levels of tumor serum markers were significantly lower in group A than in group B(P<0.05).Patients in groups A and B had mild-to-moderate fever and vomiting symptoms,which improved with conservative treatment.The total incidence of adverse reactions was significantly higher in group B(22.09%)than in group A(6.97%

关 键 词：Primary hepatocellular carcinoma Iodized oil Drug-carrying microspheres Transhepatic arterial chemo-embolization Propensity-score matching Curative effect 

分 类 号：R735.7[医药卫生—肿瘤]