New rabbit model for benign biliary stricture formation with repeatable administration  

作　　者：Qiu-Yue Sun Yi-Ming Cheng Yu-Hui Sun Jin Huang 

机构地区：[1]Department of Gastroenterology,The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University,Changzhou 213161,Jiangsu Province,China [2]Department of Gastroenterology,Graduate School of Nanjing Medical University,Nanjing 211166,Jiangsu Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第11期3538-3545,共8页世界胃肠外科杂志（英文）

基　　金：Supported by The Key Project of Changzhou Medical Center of Nanjing Medical University,No.CMCM202310 and No.CMCC202209;Science and Technology Development Fund of Nanjing Medical University,No.NMUB20220196.

摘　　要：BACKGROUND The treatment of benign biliary strictures(BBS)is a challenging clinical problem.At present,there is a lack of ideal models for the study of BBS treatment.AIM To develop a novel animal model of BBS to simulate studies on the processes and mechanisms in the human condition.METHODS A rabbit model of benign bile duct stricture was established by surgical injury of the bile duct.After removal of the gallbladder,a drainage tube was placed th-rough the cystic duct at the stump,and a BBS model was induced by surgical injury at the lower end of the common bile duct.RESULTS Compared with the control group,the model rabbits showed gross jaundice,increased serum bilirubin,and decreased liver function.Cholangiography showed segmental bile duct stenosis in the model rabbits.Pathological staining showed inflammatory cell infiltration and fibrosis in the biliary tract of rabbits in the model group.This was consistent with the clinical manifestations of BBS.This model provided serology,imaging,pathology,and other aspects of BBS.CONCLUSION We have successfully established an animal model of benign stricture of the lower bile duct with repeatable administration,which is consistent with the clinical manifestations of BBS.

关 键 词：Benign biliary stricture Animal model CHOLANGIOGRAPHY SURGERY Histopathological analysis 

分 类 号：R575.6[医药卫生—消化系统]