Effect of colorectal cancer stem cells on the development and metastasis of colorectal cancer  

作　　者：Run-Zhi Deng Xin Zheng Zhong-Lei Lu Ming Yuan Qi-Chang Meng Tao Wu Yu Tian 

机构地区：[1]College of Biological Science and Engineering,Fuzhou University,Fuzhou 350108,Fujian Province,China [2]Department of Hepatobiliary Surgery,Peking University Shenzhen Hospital,Shenzhen 518036,Guangdong Province,China [3]Department of General Surgery,Peking University First Hospital,Beijing 100034,China [4]Department of General Surgery,West China Hospital of Sichuan University,Chengdu 610044,Sichuan Province,China [5]Department of Thoracic Surgery,Yancheng No.1 People’s Hospital,Affiliated Hospital of Nanjing University Medical School,The First People’s Hospital of Yancheng,Yancheng 224000,Jiangsu Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2024年第11期4354-4368,共15页世界胃肠肿瘤学杂志（英文）

摘　　要：The relevant mechanism of tumor-associated macrophages(TAMs)in the treatment of colorectal cancer patients with immune checkpoint inhibitors(ICIs)is discussed,and the application prospects of TAMs in reversing the treatment tolerance of ICIs are discussed to provide a reference for related studies.As a class of drugs widely used in clinical tumor immunotherapy,ICIs can act on regulatory molecules on cells that play an inhibitory role-immune checkpoints-and kill tumors in the form of an immune response by activating a variety of immune cells in the immune system.The sensitivity of patients with different types of colorectal cancer to ICI treatment varies greatly.The phenotype and function of TAMs in the colorectal cancer microenvironment are closely related to the efficacy of ICIs.ICIs can regulate the phenotypic function of TAMs,and TAMs can also affect the tolerance of colorectal cancer to ICI therapy.TAMs play an important role in ICI resistance,and making full use of this target as a therapeutic strategy is expected to improve the immunotherapy efficacy and prognosis of patients with colorectal cancer.

关 键 词：Colorectal cancer Colorectal cancer stem cells Tumor metastasis Tumor immune microenvironment REVIEW 

分 类 号：R735.34[医药卫生—肿瘤]