Comparison of clinical features of patients with or without severe gastrointestinal complications in aggressive gastrointestinal lymphomas  

作　　者：Xiao-Hong Liu Gong Chen De-Dong Cao Hui Liu Xiao-Kang Ke Yu-Gang Hu Wei Tan Dong Ke Xi-Ming Xu 

机构地区：[1]Department of Cancer Center,Renmin Hospital of Wuhan University,Wuhan 430000,Hubei Province,China [2]Department of Hematology,Renmin Hospital of Wuhan University,Wuhan 430000,Hubei Province,China [3]Department of Pathology,Renmin Hospital of Wuhan University,Wuhan 430000,Hubei Province,China [4]Department of Ultrasound Imaging,Renmin Hospital of Wuhan University,Wuhan 430000,Hubei Province,China [5]Department of Gastroenterology,Renmin Hospital of Wuhan University,Wuhan 430000,Hubei Province,China [6]Department of Gastrointestinal Surgery,Renmin Hospital of Wuhan University,Wuhan 430000,Hubei Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2024年第11期4409-4423,共15页世界胃肠肿瘤学杂志（英文）

摘　　要：BACKGROUND Aggressive primary gastrointestinal non-Hodgkin lymphoma(PGINHL)is an uncommon and heterogeneous group of lymphoid malignancies,that differs from indolent lymphoma and has a high incidence of severe gastrointestinal complications(GICs).AIM To investigate and compare the clinicopathological characteristics,treatments and outcomes in the GICs and No-GICs group with aggressive PGINHL.METHODS This retrospective analysis was performed on aggressive PGINHL patients between January 2013 and December 2021 at our hospital.The independent influence factors of GICs were obtained by univariate and multivariate Logistic regression analysis,the selected variables significantly related to GICs were selected as the final predictors to construct nomogram.Kaplan-Meier curves further analyzed the survival of patients in GICs and No-GICs groups.Survival analysis of GICs group was performed using Cox regression.RESULTS We focused on 124 aggressive PGINHL cases,which had a relatively high incidence 48.4%(60/124 cases)of GICs,the most common histological type in GICs group was diffuse large B-cell lymphoma(DLBCL)(n=49,81.7%).In the GICs group,small intestine was the most common anatomic site of lesion(43.3%),followed by large intestine(31.7%),and then stomach and esophagus(25.0%).Multivariate Logistic regression analysis showed that the independent risk factors for GICs were the small intestine[odd ratio(OR)=3.33;95%confidence interval(CI):1.47-9.41;P=0.009),aggressive B-cell(OR=0.09;95%CI:0.01-0.83;P=0.033),maximum tumor diameter(OR=1.25;95%CI:1.07-1.47;P=0.005),invaded deep serous layer(OR=3.38;95%CI:1.24-9.19;P=0.017).We developed a nomogram to predict risk of GICs in aggressive PGINHL patients based on independent risk factors.The value of area under curve calculated by receiver operating characteristic curve was 0.815,and calibration curve and decision curve analysis further indicated that the prediction effect was superior.The majority of patients with GICs were given combination therapy(chemotherapy combined with surg

关 键 词：Primary gastrointestinal AGGRESSIVE Non-Hodgkin lymphoma Gastrointestinal complication Risk factor 

分 类 号：R735[医药卫生—肿瘤]