Local excision for middle-low rectal cancer after neoadjuvant chemoradiation:A retrospective study from a single tertiary center  

作　　者：Nan Chen Chang-Long Li Lin Wang Yun-Feng Yao Yi-Fan Peng Tian-Cheng Zhan Jun Zhao Ai-Wen Wu 

机构地区：[1]Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Gastrointestinal Center,Unit III,Peking University Cancer Hospital and Institute,Beijing 100142,China

出　　处：《World Journal of Gastrointestinal Oncology》2024年第12期4614-4624,共11页世界胃肠肿瘤学杂志（英文）

基　　金：Supported by Beijing Municipal Administration of Hospitals Incubating Program,No.PZ2020027;Beijing Talent Incubating Funding,No.2019-4;National Natural Science Foundation of China,No.81773214;Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support,No.ZYLX202116;National Key R and D Program of China,No.2021YFF1201104;2019 Major and Difficult Diseases Chinese and Western Medicine Coordination Capacity Colorectal Cancer Project,No.(2018)275;Science Foundation of Peking University Cancer Hospital-2023,No.JC202310;Natural Science Project of Chifeng City,No.2023-114.

摘　　要：BACKGROUND Rectal cancer has become one of the leading malignancies threatening people’s health.For locally advanced rectal cancer(LARC),the comprehensive strategy combining neoadjuvant chemoradiotherapy(NCRT),total mesorectal excision(TME),and adjuvant chemotherapy has emerged as a standard treatment regimen,leading to favorable local control and long-term survival.However,in recent years,an increasing attention has been paid on the exploration of organ preservation strategies,aiming to enhance quality of life while maintaining optimal oncological treatment outcomes.Local excision(LE),compared with low anterior resection(LAR)or abdominal-perineal resection(APR)was introduced dating back to 1970’s.LE has historically been linked to a heightened risk of recurrence compared to TME,potentially due to occult lymph node metastasis and intraluminal recurrence.Recent evidence has demonstrated that LE might be an alternative approach,instead of LAR or APR,in cases with favorable tumor regression after NCRT with potentially better quality of life.Therefore,a retrospective analysis of clinicopathological data from mid-low LARC patients who underwent LE after NCRT was conducted,aiming to evaluate the treatment's efficacy,safety,and oncologic prognosis.AIM To explore the safety,efficacy,and long-term prognosis of LE in patients with mid-low rectal cancer who had a good response to NCRT.METHODS Patients with LE between 2012 to 2021 were retrospectively collected from the rectal cancer database from Gastro-intestinal Ward III in Peking University Cancer Hospital.The clinicopathological features,postoperative complications,and long-term prognosis of these patients were analyzed.The Kaplan-Meier method was used to create cancer-specific survival curve,and the log-rank test was used to compare the differences regarding outcomes.RESULTS A total of 33 patients were included in this study.The median interval between NCRT and surgery was 25.4(range:8.7-164.4)weeks.The median operation time was 57(20.0-137.0)minutes.The initial cl

关 键 词：Rectal cancer Neoadjuvant chemoradiotherapy Local excision PROGNOSIS 

分 类 号：R735[医药卫生—肿瘤]