Use of traditional Chinese medicine bezoars and bezoar-containing preparations in hepatocarcinoma  

作　　者：De-Hui Li Qian-Er Wen Rui-Qi Feng Chang Qiao Xiao-Tong Tian 

机构地区：[1]Department of Oncology II,The First Affiliated Hospital of Hebei University of Chinese Medicine(Hebei Province Hospital of Chinese Medicine),Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research,Hebei Industrial Technology Institute for Traditional Chinese Medicine Preparation,Shijiazhuang 050000,Hebei Province,China [2]Graduate School,Hebei University of Chinese Medicine,Shijiazhuang 050000,Hebei Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2024年第12期4770-4777,共8页世界胃肠肿瘤学杂志（英文）

基　　金：Supported by 2023 Government-funded Project of The Outstanding Talents Training Program in Clinical Medicine,No.ZF2023165;Key Research and Development Projects of Hebei Province,No.18277731D;and Natural Science Foundation of Hebei Province,No.H202423105.

摘　　要：This manuscript used network pharmacology and experimental verification to analyze the anti-hepatocarcinoma mechanism of action of bezoars in traditional Chinese medicine(TCM),discovering that it can affect the immune cells within the tumor microenvironment and related pathways to produce inhibitory effects in liver cancer.In TCM,bezoars have a unique therapeutic advantage in the prevention and treatment of tumors.They play an anti-tumorigenic role by regulating the immune microenvironment through multi-component,multi-target and multi-pathway mechanisms.With the application of nanotechnology,bezoars and their compound preparations have been developed into anti-cancer drugs with unique therapeutic advantages,providing novel treatment options for tumor patients.

关 键 词：BEZOAR Traditional Chinese medicine Liver cancer Immune microenvironment Network pharmacology 

分 类 号：R735.7[医药卫生—肿瘤]