Crosslink among cyclin-dependent kinase 9,ATP binding cassette transporter G2 and Beclin 1 in colorectal cancer  

作　　者：Zhong-Bao Shao Ke He Yu-Bin Su Zhi Shi 

机构地区：[1]Cancer Minimally Invasive Therapies Centre,Guangdong Second Provincial General Hospital,Jinan University,Guangzhou 510632,Guangdong Province,China [2]Department of Cell Biology&Institute of Biomedicine,Guangdong Provincial Biotechnology&Engineering Technology Research Center,Guangdong Provincial Key Laboratory of Bioengineering Medicine,Genomic Medicine Engineering Research Center of Ministry of Education,MOE Key Laboratory of Tumor Molecular Biology,National Engineering Research Center of Genetic Medicine,State Key Laboratory of Bioactive Molecules and Druggability Assessment,College of Life Science and Technology,Jinan University,Guangzhou 510632,Guangdong Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2024年第12期4778-4781,共4页世界胃肠肿瘤学杂志（英文）

基　　金：Supported by the National Natural Science Foundation of China,No.82272996;the Science and Technology Program of Guangzhou,No.202206010081.

摘　　要：Colorectal cancer(CRC)ranks third in the number of cancers mainly because of the inability to diagnose it at an early stage.The pathogenesis of CRC is complicated,which is the result of the complex interaction of multiple genetic and environmental factors.Currently,one of the main treatments for CRC is chemotherapy.But the primary cause of CRC treatment failure is drug resistance.The expression of cyclin-dependent kinase 9(CDK9)was correlated with elevated autophagy levels in colon cancer,and high expression of CDK9 indicates a poor prognosis in CRC.The incidence of autophagy and the expressions of Beclin 1 and ATP binding cassette transporter G2 are different in left and right colon cancer,and autophagy may be involved in the occurrence of chemotherapy resistance.In this article,the roles of CDK9,ATP binding cassette transporter G2 and Beclin 1 in CRC were elucidated,emphasizing the linkages among them and providing potential therapeutic targets of CRC.

关 键 词：Cyclin-dependent kinase 9 ATP binding cassette transporter G2 Beclin 1 Colorectal cancer CHEMOTHERAPY 

分 类 号：R735.34[医药卫生—肿瘤]