类淋巴系统在脑疾病发生、发展中的作用和机制研究进展  

Research progress on the role and mechanism of the glymphatic system in the occurrence anddevelopment of brain diseases

作　　者：畅君雷 冯梓莹 CHANG Junlei;FENG Ziying(Institute of Biomedicine and Technology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China)

机构地区：[1]中国科学院深圳先进技术研究院生物医药与技术研究所,深圳518055

出　　处：《广西医科大学学报》2024年第10期1418-1424,共7页Journal of Guangxi Medical University

摘　　要：近年来的生物医学研究揭示了大脑通过类淋巴系统清除神经组织产生的代谢废物的新机制。这一系统有效促进了脑脊液与脑间质液的交换,类似于外周淋巴系统,发挥着清除脑内代谢废物的作用,对维持大脑内微环境稳态至关重要。越来越多的研究发现,在多种脑疾病条件下类淋巴系统功能受损,可能是各种脑疾病发生、发展的关键促进因素。因此,理解类淋巴系统在脑疾病中的作用和机制对于制定新的靶向治疗策略具有重要意义。Biomedical research in recent years has revealed a new mechanism by which the brain can effectively remove metabolic waste generated by the neural tissue through the glymphatic system.This system efficiently promotes the exchange of cerebrospinal fluid and brain interstitial fluid,which is similar to the peripheral lymphatic system.It plays a role in removing metabolic waste in the brain and is essential to maintain the homeostasis of the brain microenvironment.An increasing number of studies have found that the function of the glymphatic system is impaired under conditions of various brain diseases,which is likely a key promoting factor in the occurrence,formulation and development of various brain diseases.Therefore,understanding the role of the glymphatic system and the underlying mechanism in brain diseases is of great significance for developing new targeted therapeutic strategies.

关 键 词：类淋巴系统 淋巴系统 脑疾病 脑脊液 水通道蛋白4 

分 类 号：R741[医药卫生—神经病学与精神病学]