声触诊组织成像定量技术联合血清胸苷激酶1检测对三阴性乳腺癌保乳术后肿瘤复发的预测价值  

Prognostic value of virtual touch tissue imaging quantitative combined with serum TK1 detection for tumor recurrence after breast preserving surgery for triple-negative breast cancer

作　　者：汤波 项燕妮 喻三梅 彭玲耀 Tang Bo;Xiang Yanni;Yu Sanmei;Peng Lingyao(Department of Ultrasound,Taizhou First People’s Hospital,Taizhou 318020,China)

机构地区：[1]台州市第一人民医院超声科,台州318020

出　　处：《中华内分泌外科杂志（中英文）》2024年第5期661-664,共4页Chinese Journal of Endocrine Surgery

基　　金：浙江省医药卫生科技项目(2023RC069)。

摘　　要：目的探讨声触诊组织成像定量技术(virtual touch tissue imaging quantification,VTIQ)联合血清胸苷激酶1(thymidine kinase1,TK1)检测对三阴性乳腺癌(triple-negative breast cancer,TNBC)保乳术后肿瘤复发的预测价值。方法选取2020年5月至2022年4月台州市第一人民医院收治的102例择期行保乳术治疗的TNBC患者为研究对象,均在手术后进行VTIQ检查,测量剪切波速度(shear wave velocity,SWV),并进行血清TK1检测。所有患者术后均随访,统计其术后2年肿瘤复发情况,采用多因素Logistic回归分析探讨TNBC保乳术后肿瘤复发的影响因素,绘制ROC曲线分析SWV和血清TK1水平对TNBC保乳术后肿瘤复发的预测价值。结果本次102例TNBC患者保乳术后2年肿瘤复发率为29.41%(30/102)。复发组TNM分期、淋巴结转移、复发组SWV和血清TK1水平高于未复发组(χ^(2)=4.42,χ^(2)=6.41,t=6.97,t=6.15,均P<0.05)。多因素Logistic回归分析,结果显示淋巴结转移、SWV和血清TK1水平是TNBC患者保乳术后2年内肿瘤复发的影响因素(OR=3.093,OR=3.501,OR=2.939,均P<0.05)。ROC曲线分析显示,SWV和血清TK1水平及其联合检测预测TNBC患者保乳术后肿瘤复发的AUC值分别为0.821、0.778、0.869,敏感度分别为66.67%、73.33%、83.33%,特异度分别为81.94%、76.39%、79.17%,SWV和血清TK1水平联合检测对TNBC患者保乳术后肿瘤复发的预测效能高于其单一检测。结论SWV和血清TK1水平与TNBC保乳术后肿瘤复发有关,可预测肿瘤复发情况,且两指标联合检测能提高对TNBC保乳术后肿瘤复发的预测效能。ObjectiveTo investigate the value of virtual touch tissue imaging quantitative(VTIQ)combined with serum thymidine kinase 1(TK1)detection in predicting the recurrence of triple negative breast cancer(TNBC)after breast preservation surgery.MethodsA total of 102 TNBC patients admitted to our hospital from May.2020 to Apr.2022 who underwent elective breast-preserving surgery were selected as the study objects.VTIQ was examined after surgery,shear wave velocity(SWV)was measured,and serum TK1 was detected.All patients were followed up after surgery,and tumor recurrence two years after surgery was statistically analyzed.Multivariate Logistic regression analysis was used to explore the influencing factors of tumor recurrence after TNBC breast-preserving preservation,and ROC curve was drawn to analyze the predictive value of SWV and serum TK1 levels on tumor recurrence.ResultsThe tumor recurrence rate of 102 TNBC patients was 29.41%(30/102)at 2 years after breast-preserving surgery.The TNM stage,lymph node metastasis,the levels of SWV and TK1 in the relapsed group were higher(χ^(2)=4.42,χ^(2)=6.41,t=6.97,t=6.15,all P<0.05).Multivariate Logistic regression analysis showed that lymph node metastasis,SWV and serum TK1 level were influential factors for tumor recurrence at 2 years after breast-preserving surgery in TNBC patients(OR=3.093,OR=3.501,OR=2.939,all P<0.05).ROC curve analysis showed that the AUC values of SWV and serum TK1 levels and their combined detection in predicting tumor recurrence after breast-preserving in TNBC patients were 0.821,0.778 and 0.869,respectively,the sensitivity was 66.67%,73.33%and 83.33%,respectively,and the specificity was 81.94%,76.39%and 79.17%,respectively.The combined detection of SWV and serum TK1 level was more effective than the single detection in predicting tumor recurrence in patients with TNBC after breast-preserving surgery.ConclusionSWV and serum TK1 levels are related to tumor recurrence after TNBC,and can predict tumor recurrence,and the combined detection of the two indicat

关 键 词：三阴性乳腺癌 保乳术 声触诊组织成像定量技术 复发 胸苷激酶1 

分 类 号：R737.9[医药卫生—肿瘤] R445.1[医药卫生—临床医学]