沙利度胺片致β地中海贫血患者继发性闭经1例分析  

One case of secondary amenorrhea caused by thalidomide tablets in aβ-thalassemia patient

作　　者：尹春燕 孔文强 杨焜 YIN Chunyan;KONG Wenqiang;YANG Kun(Department of Pharmacy,Zigong First People’s Hospital,Zigong Sichuan 643000,China;Department of Hematology,Zigong First People’s Hospital,Zigong Sichuan 643000,China)

机构地区：[1]自贡市第一人民医院药剂科,四川自贡643000 [2]自贡市第一人民医院血液科,四川自贡643000

出　　处：《中国药物警戒》2024年第10期1181-1183,共3页Chinese Journal of Pharmacovigilance

摘　　要：目的探讨沙利度胺导致β地中海贫血患者继发性闭经的临床特征及发病机制。方法分析1例β地中海贫血患者接受沙利度胺片治疗致继发性闭经病例,结合相关文献,讨论临床表现及发生机制。结果患者在沙利度胺治疗5个月后出现闭经,停用4个月后,月经再次出现,激素恢复正常水平,考虑该闭经不良反应很可能为沙利度胺引起。结论沙利度胺可以导致高促性腺激素闭经,在治疗期间需警惕其发生的可能。Objective To explore the clinical characteristics and mechanism of secondary amenorrhea caused by thalidomide in aβ-thalassemia patient.Methods Secondary amenorrhea caused by thalidomide in aβ-thalassemia patient was analyzed,while the manifestations and pathogenesis were summarized based on literature review.Results The patient developed amenorrhea after 5 months of thalidomide treatment.Four months later,spontaneous menses returned and her hormonal profile returned to normal.The adverse reaction was believed to have been caused by thalidomide.Conclusion Thalidomide can cause hypergonadotropin amenorrhea,so clinicians should be alert to the risk during treatment.

关 键 词：沙利度胺 药品不良反应 继发性闭经 月经 贫血 地中海贫血 

分 类 号：R973[医药卫生—药品] R994.11[医药卫生—药学]