纳米消融术辅助PTCD治疗晚期胆囊癌的效果分析  

Effect analysis of nano ablation assisted PTCD in the treatment of advanced gallbladder cancer

作　　者：李贝贝[1] 孟德敏 LI Beibei;MENG Demin(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院,郑州450000

出　　处：《华夏医学》2024年第5期96-101,共6页Acta Medicinae Sinica

基　　金：河南省医学科技攻关项目(LHGJ202001341)。

摘　　要：目的分析纳米消融术辅助经皮肝穿刺胆道引流术(PTCD)治疗晚期胆囊癌的效果。方法选取106例晚期胆囊癌患者,按照随机数字表法分为手术组和联合组,每组53例。手术组采用PTCD治疗,联合组采用纳米消融术辅助PTCD治疗,比较两组的近期疗效及短期预后情况。结果术后1周、4周,联合组的血清总胆红素(TBIL)水平、糖类抗原199(CA199)、谷丙转氨酶(ALT)、谷草转氨酶(AST)均低于手术组,差异有统计学意义(P<0.05);联合组T淋巴细胞亚群CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均高于手术组(P<0.05);联合组1年内生存率、中位无进展生存期(PFS)、中位总生存期(OS)均高于手术组(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论纳米消融术辅助PTCD治疗,能增强晚期胆囊癌患者近期疗效,减轻肝损伤,增强免疫功能,对改善患者短期预后有积极意义。Objective To observe the effects of nano ablation assisted percutaneous transhepatic cholangial drainage(PTCD)in the treatment of advanced gallbladder cancer.Methods 106 patients with advanced gallbladder cancer were randomly divided into the surgical group and combination group using computer randomization,with 53 patients in each group.The surgical group were received PTCD treatment,while the combination group were received nano ablation assisted PTCD treatment.The short-term efficacy and prognosis were compared between the two groups.Results At 1 and 4 weeks after surgery,the levels of total bilirubin(TBIL),carbohydrate antigen 199(CA199),alanine aminotransferase(ALT),and aspartate aminotransferase(AST)in the combined group were lower than those in the surgical group,and the differences were statistically significant(P<0.05).The T lymphocyte subsets CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in the combined group were higher than those in the surgical group(P<0.05).The one-year survival rate,median progression free survival(PFS),and median overall survival(OS)of the combined group were higher than those of the surgical group(P<0.05).There was no statistically significant difference in the incidence of complications between the two groups(P>0.05).Conclusion Nano ablation assisted PTCD can enhance the short-term efficacy of advanced gallbladder cancer patients,reduce liver damage,enhance immune function without increasing treatment risk,and have positive significance in improving the short-term prognosis of patients.

关 键 词：晚期胆囊癌 纳米消融术 经皮肝穿刺胆道引流术 

分 类 号：R735.8[医药卫生—肿瘤]