阿加曲班联合丁咯地尔对脑供血不足性眩晕症的治疗作用  

Therapeutic effects of agatroban combined with buflomedil on cerebral insufficiency of blood supply vertigo

作　　者：杨柳 魏超 YANG Liu;WEI Chao(Department of Neurology,General Hospital of Yima Coal Industry Group Co.,Ltd.,Yima 472300,China;Department of Neurology,Xi′an No.9 Hospital,Xi′an 710000,China)

机构地区：[1]义马煤业集团股份有限公司总医院神经内科,义马472300 [2]西安市第九医院神经内科,西安710000

出　　处：《华夏医学》2024年第5期161-167,共7页Acta Medicinae Sinica

基　　金：河南省医学科技攻关联合共建项目(LHGJ20201544)。

摘　　要：目的探究阿加曲班联合丁咯地尔对脑供血不足性眩晕症的治疗作用。方法选取2021年1月至2023年6月收治的脑供血不足性眩晕症患者102例,根据治疗方法不同分为对照组和观察组。对照组51例,以丁咯地尔治疗;观察组51例,以阿加曲班+丁咯地尔治疗。比较两组临床疗效,不良反应发生率,治疗前后脑动脉血流相关指标[阻力指数(RI)、搏动指数(PI)、舒张末期流速(Vd)、峰值流速(Vp)、平均血流速度(Vm)],氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)],血清因子[白细胞介素增强结合因子-1(ILF-1)、降钙素基因相关肽(CGRP)、内皮素-1(ET-1)、C反应蛋白(CRP)]。结果观察组临床治疗总有效率为92.16%,高于对照组76.47%,差异有统计学意义(P<0.05);治疗后,观察组脑动脉血流相关指标、氧化应激指标及血清因子水平改善优于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论阿加曲班联合丁咯地尔可有效提高脑供血不足性眩晕症患者的治疗效果。Objective To explore the therapeutic effects of argatroban combined with buflomedil on cerebral insufficiency of blood supply vertigo.Methods 102 patients with cerebral insufficiency of blood supply vertigo who were treated from Jan.2021 to Jun.2023 were selected and divided the control group and observation group according to different treatment methods.51 patients in the control group were treated with buflomedil.51 patients in the observation group were treated with argatroban and buflomedil.The clinical efficacy and incidence of adverse reactions were compared between the two groups,as well as the cerebral artery blood flow-related indicators before and after treatment,including resistance index(RI),pulsatility index(PI),end diastolic velocity(Vd),peak velocity(Vp),and mean blood flow velocity(Vm).Additionally,the oxidative stress indicators,including superoxide dismutase(SOD)and malondialdehyde(MDA),and serum factors including interleukin-1 binding factor-1(ILF-1),calcitonin gene-related peptide(CGRP),endothelin-1(ET-1),and C-reactive protein(CRP)were also compared.Results The total effective rate of clinical treatment in the observation group was 92.16%,which was higher than 76.47%in the control group,and the difference was statistically significant(P<0.05).After treatment,the improvement of cerebral artery blood flow related indicators,oxidative stress indicators,and serum factor levels in the observation group was better than that in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Agapurin combined with buflomedil effectively improves the treatment effect of patients with cerebral insufficiency of blood supply vertigo.

关 键 词：阿加曲班 丁咯地尔 脑供血不足性眩晕症 脑血流动力学 

分 类 号：R741[医药卫生—神经病学与精神病学]