卵巢透明细胞癌30例临床病理特征分析  

Analysis on clinicopathological features in 30 cases of ovarian clear cell carcinoma

作　　者：柳秋月 张荣君[1] 汤须崇[2] LIU Qiuyue;ZHANG Rongjun;TANG Xuchong(Department of Pathology,Jinjiang Municipal Hospital/Fujian Hospital,Shanghai Municipal Sixth People’s Hospital,Jinjiang,Fujian 362200,China;Institute of Advanced Carbon Conversion Technology,Huaqiao University,Xiamen,Fujian 350305,China)

机构地区：[1]晋江市医院/上海市第六人民医院福建医院病理科,福建晋江362200 [2]华侨大学先进碳转化技术研究院,厦门350305

出　　处：《重庆医学》2024年第21期3295-3299,共5页Chongqing Medical Journal

摘　　要：目的研究卵巢透明细胞癌的临床病理特征,为明确是否起源于内膜样囊肿的鉴别诊断提供依据。方法收集2009年1月至2022年12月在晋江市医院接受治疗的30例卵巢透明细胞癌患者作为研究对象。将非起源于内膜样囊肿的患者纳入对照组(n=15),起源于内膜样囊肿的患者纳入观察组(n=15)。采用巨检、镜检、苏木精-伊红染色、免疫组织化学染色进行临床病理特征分析,统计和分析两组患者一般资料及病理检查结果。结果两组患者中,透明细胞22例(73.33%)、鞋钉样细胞3例(10.00%)、两种细胞各占约一半者2例(6.67%)、出现透明小体或嗜酸性细胞3例(10.00%);天冬氨酸肽酶-A(Napsin-A)阳性27例(90.00%),肝细胞核因子-1β(HNF-1β)阳性29例(96.67%)。分期、腹水、淋巴结转移、腹/盆腔转移、CA125、并发内膜样囊肿、囊内含咖啡色液体、囊壁厚薄不均、月经紊乱、不孕症均为卵巢透明细胞癌源于内膜样囊肿的影响因素(P<0.05)。结论相关病理特征能为卵巢透明细胞癌是否起源于内膜样囊肿的临床鉴别诊断提供重要参考依据,对提升卵巢透明细胞癌检出率有重要意义。Objective To study the clinicopathological features of ovarian clear cell carcinoma to provide a basis for the differential diagnosis of whether it originates from endometrioid cyst.Methods A total of 30 patients with ovarian clear cell carcinoma receiving treatment in Jinjiang Municipal Hospital from January 2009 to December 2022 were collected as the research subjects.The patients not originating from endometrioid cysts were included in the control group(n=15)and the patients originating from endometrioid cysts were included in the observation group(n=15).Macroexamination,microscopic examination,hematoxylin-eosin staining and immunohistochemical staining were used to analyze the clinicopathological characteristics.The general data and pathological examination results of the two groups were statistically analyzed.Results Among the two groups,there were 22 cases(73.33%)of clear cells,3 cases(10.00%)of shoe-tack like cells,2 cases(6.67%)with about half of each cell type,and 3 cases(10.00%)of hyaline bodies or eosinophils.There were 27 cases(90.00%)of aspartic acid peptidase A(Napsin-A)positive and 29 cases(96.67%)of hepatocyte nuclear factor-1β(HNF-1β)positive.Staging,ascites,lymph node metastasis,abdominal/pelvic metastasis,CA125,complicating endometrioid cyst,coffee-colored fluid in the sac,uneven thickness of the cyst wall,menstrual disorders and infertility all were the influencing factors of ovarian clear cell carcinoma originating from endometrioid cyst(P<0.05).Conclusion The relevant pathological features could provide an important reference base for the clinical differential diagnosis of whether ovarian clear cell carcinoma originates from endometrioid cysts,and it is of great significance to improve the detection rate of ovarian clear cell carcinoma.

关 键 词：卵巢透明细胞癌 内膜样囊肿 临床病理特征 鉴别诊断 

分 类 号：R737.31[医药卫生—肿瘤]