含奥沙利铂的一线化疗对左右半结肠癌的临床效果对比研究  

Comparative study on the clinical efficacy of first-line chemotherapy containing oxaliplatin on left and right colon cancer

作　　者：章宝繁 吴圣豪 ZHANG Baofan;WU Shenghao(Second Department of Oncology,Second Affiliated Hospital of Shanghai University,Wenzhou 325000,Zhejiang,China;Department of Blood Chemotherapy,Second Affiliated Hospital of Shanghai University,Wenzhou 325000,Zhejiang,China)

机构地区：[1]上海大学附属第二医院肿瘤内二科,浙江温州325000 [2]上海大学附属第二医院血液化疗科,浙江温州325000

出　　处：《中国现代医生》2024年第31期68-71,共4页China Modern Doctor

摘　　要：目的比较含奥沙利铂的一线化疗对左半结肠癌和右半结肠癌的临床疗效。方法选取2020年1月至2024年1月于上海大学附属第二医院就诊的结肠癌患者120例,根据肿瘤所在位置将其分为左半结肠癌组(60例)和右半结肠癌组(60例)。两组患者均给予含奥沙利铂的一线化疗方案治疗2个周期,比较两组患者的疾病控制率、血清肿瘤标志物、血清炎症因子、癌因性症状评分、生存质量和不良反应发生率。结果治疗后,左半结肠癌组患者的疾病控制率显著优于右半结肠癌组(χ^(2)=22.224,P<0.001);左半结肠癌组患者的血清癌胚抗原、糖类抗原125、糖类抗原153、C反应蛋白、白细胞介素-6水平均显著低于右半结肠癌组(P<0.05);左半结肠癌组患者的癌因性疼痛评分、癌因性疲乏评分均显著低于右半结肠癌组(P<0.05);左半结肠癌组患者的生存质量优于右半结肠癌组(P<0.05)。结论含奥沙利铂的一线化疗对左半结肠癌患者的近期疗效更好,肿瘤进展控制良好,患者的临床症状得以改善,生存质量得以提高。Objective To compare the clinical effect of first-line chemotherapy containing oxaliplatin on left and right colon cancer.Methods A total of 120 patients with colon cancer admitted to Second Affiliated Hospital of Shanghai University from January 2020 to January 2024 were selected and divided into left colon cancer group(60 cases)and right colon cancer group(60 cases)according to tumor location.Both groups were treated with first-line chemotherapy containing oxaliplatin for 2 cycles.Disease control rate,serum tumor markers,serum inflammatory factors,cancer-causing symptom scores,quality of life and incidence of adverse reactions were compared between two groups.Results After treatment,disease control rate in left colon cancer group was significantly higher than that in right colon cancer group(χ^(2)=22.224,P<0.001).The levels of serum carcinoembryonic antigen,carbohydrate antigen 125,carbohydrate antigen 153,C-reactive protein and interleukin-6 of left colon cancer group were lower than those of right colon cancer group(P<0.05).The scores of cancer-related pain and fatigue of left colon cancer group were lower than those of right colon cancer group(P<0.05).The quality of life in left colon cancer group was better than that in right colon cancer group(P<0.05).Conclusion First-line chemotherapy containing oxaliplatin has better short-term efficacy in patients with left colon cancer,with better control of tumor progression,and can improre clinical symptoms and quality of life.

关 键 词：左半结肠癌 右半结肠癌 化疗 奥沙利铂 

分 类 号：R735.35[医药卫生—肿瘤]