外侧缰核及其神经环路在重度抑郁症中的作用  

The role of the lateral habenula nucleus and its neural circuit in major depressive disorder

作　　者：赵国建 齐月 张子炜 杨梅[1,4] 黄志华 唐晓璐 ZHAO Guo-jian;QI Yue;ZHANG Zi-wei;YANG Mei;HUANG Zhi-hua;TANG Xiao-lu(Key Laboratory of Ministry of Education for Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases,Gannan Medical University;School of Rehabilitation Medicine,Gannan Medical University;School of Basic Medicine,Gannan Medical University;The First Clinical Medical School,Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医科大学心脑血管疾病防治教育部重点实验室 [2]赣南医科大学康复学院 [3]赣南医科大学基础医学院 [4]赣南医科大学第一临床医学院,江西赣州341000

出　　处：《赣南医科大学学报》2024年第10期988-992,1042,共6页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：江西省自然科学基金面上项目(20224BAB206035);江西省自然科学基金青年一般项目(20202BABL216082)。

摘　　要：重度抑郁症(Major depressive disorder,MDD)是常见的情绪障碍性疾病,近年来发病率呈逐年上升趋势。外侧缰核(Lateral habenula,LHb)位于上丘脑,参与恐惧、焦虑、抑郁等负性情绪编码。研究表明,LHb异常活动与MDD的发生发展密切相关,是MDD研究领域的重要脑区。本文就外侧缰核细胞构筑、纤维联系及其在重度抑郁症中的相关神经环路机制进行综述。文献复习结果发现,LHb介导抑郁相关的神经环路包括外侧缰核-腹侧被盖区、中缝背核-外侧缰核、腹侧苍白球-外侧缰核、下丘脑穹窿周围区/外侧区-外侧缰核、无名核-外侧缰核、内侧前额叶皮质-外侧缰核、腹侧被盖区-外侧缰核。这为MDD的发病机制及其治疗新药的研发提供新的思路和靶点。Major depressive disorder(MDD)is a prevalent emotional disorder,with its incidence rate showing an annual increase.The lateral habenula(LHb),situated in the epithalamus,plays a role in encoding negative emotions such as fear,anxiety,and depression.Research indicates that abnormal activity in the LHb is closely related to the onset and development of MDD,making it a significant brain region in MDD research.This article provides a brief overview of the cellular architecture,fiber connections,and related neural circuit mechanisms of the LHb in MDD.A review of the literature reveals that the LHb mediates depression-related neural circuits,including the lateral habenula-ventral tegmental area,dorsal raphe nucleus-lateral habenula,ventral pallidum-lateral habenula,lateral hypothalamic arealateral habenula,substantia innominata-lateral habenula,medial prefrontal cortex-lateral habenula,and ventral tegmental area-lateral habenula.This provides new insights and targets for understanding the pathogenesis of MDD and the development of new therapeutic drugs.

关 键 词：重度抑郁症 外侧缰核 神经环路 

分 类 号：R749.99[医药卫生—神经病学与精神病学]