D-半乳糖诱导脑老化模型机制的研究进展  

Research progress on the mechanism of D-galactose-induced brain aging model

作　　者：朱紫悦 金美玲 许翔月 刘晴 朱嘉雪 付明军 雷霞 张宁[3] ZHU Ziyue;JIN Meiling;XU Xiangyue;LIU Qing;ZHU Jiaxue;FU Mingjun;LEI Xia;ZHANG Ning(College of Basical Medical Science,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Wuxi Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Wuxi 214071;Heilongjiang University of Chinese Medicine,Harbin 150040)

机构地区：[1]黑龙江中医药大学基础医学院,哈尔滨150040 [2]南京中医药大学无锡附属医院,江苏无锡214071 [3]黑龙江中医药大学,哈尔滨150040

出　　处：《中国比较医学杂志》2024年第10期104-110,117,共8页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金面上项目(82174007);无锡市卫生健康委中青年拔尖人才资助计划(BJ2023072);无锡市卫生健康委科研项目(M202206)。

摘　　要：D-半乳糖(D-galactose, D-gal)作为正常的生理物质,过量摄入能在体内外引发类似自然脑衰老的过程,故在国内外被广泛用来诱导脑老化模型。D-半乳糖诱发的脑衰模型耗时短、成本低、效果明显,但其诱导机制复杂多样,各机制间的关系尚不明确,导致目前该模型的实际运用存在局限性。本文就D-半乳糖的体内代谢和诱导脑老化的各种机制,以及机制间的联系作一综述,旨在为该模型的运用发展和脑衰老的深入研究提供参考。As a normal physiological substance,D-galactose can induce a process similar to natural brain aging in vivo and in vitro when administered excessively,and thus it is widely used to induce brain aging models in China and abroad.The model of brain failure induced by D-galactose has the advantages of a short modeling time,low cost,and significant effect.However,the induction mechanisms are complex and diverse,and the relationships between the mechanisms are unclear,which limit the practical applications of the model.This article reviews the in vivo metabolism of D-galactose and the various mechanisms involved in the induction of brain aging,as well as the links between the mechanisms,to provide a reference for the application and development of this model and the in-depth study of brain aging.

关 键 词：脑老化 D-半乳糖 模型机制 

分 类 号：R-33[医药卫生]