脂质代谢和脂类营养干预在儿童癌症中的研究进展  

A minireview on lipid metabolism and lipid-associated nutritional interventions in childhood cancers

作　　者：沈嫣然 毕心语 龚阳奕 宋恩名 陶灵 SHEN Yanran;BI Xinyu;GONG Yangyi;SONG Enming;TAO Ling(School of Public Health/Institute of Nutrition,Fudan University,Shanghai 200032,China;Institute of Optoelectronics/Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception,Fudan University,Shanghai 200433,China;State Key Laboratory of Medical Neurobiology/MOE Frontiers Center for Brain Science,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学公共卫生学院/营养研究院(筹),上海200032 [2]复旦大学光电研究院/上海市智能光电与感知前沿科学研究基地,上海200433 [3]复旦大学脑功能与脑疾病全国重点实验室/脑科学前沿科学中心,上海200032

出　　处：《环境与职业医学》2024年第8期934-940,共7页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金项目(82304124)。

摘　　要：癌症是儿童时期死亡的重要原因,患儿往往面临巨大的疾病负担。脂质代谢重编程是肿瘤最重要的标志之一,其在理解肿瘤发生机制、寻找治疗手段、改善预后等方面都具有研究意义。然而,与成人癌症相比,儿童癌症相关的脂质代谢和脂类营养干预研究十分有限。本文着重介绍了当前儿童癌症中脂肪酸、胆固醇以及磷脂的代谢特性,并讨论了主要脂类饮食模式(如高脂、生酮、地中海饮食等)与儿童肿瘤发生和发展的相关性。本文同时指出了在脂质代谢的机制以及主要脂类饮食模式的研究方面存在的不足,包括研究深度、实验设计、样本量等方面有待完善。因此,我们期望未来能在儿童癌症领域进一步开展流行病学、基础科学以及多学科交叉研究,从而更全面、更深入地理解脂类营养在预防和治疗儿童癌症中的重要作用。Cancer is a leading cause of mortality in children and results in a significant disease burden.Lipid metabolic reprogramming emerges as a pivotal cancer hallmark,bearing profound implications for understanding tumorigenesis,developing treatment strategies,and improving prognoses.However,research on lipid metabolism and lipid nutritional interventions related to childhood cancers is notably limited compared to adult cancers.This review focused on the current understanding of fatty acid,cholesterol,and phospholipid metabolism in childhood cancers and discussed the correlation between major lipid dietary patterns(such as high-fat,ketogenic,and Mediterranean diets)and the development and progression of childhood cancers.This review also highlighted existing research gaps on the mechanisms of lipid metabolism and the effects of major lipid dietary patterns,and warranted improved research depth,experimental design,and sample size.Therefore,we advocate for future epidemiological,basic science,and multidisciplinary research in the field of childhood cancers to understand more comprehensively and profoundly the role of lipid nutrition in the prevention and treatment of pediatric cancers.

关 键 词：脂质代谢 儿童癌症 营养干预 

分 类 号：R15[医药卫生—营养与食品卫生学]