基于独立成分分析的青少年抑郁症默认网络和情感调控网络的研究  

Study of default mode network and affective network among adolescents with depressive disorder based on independent component analysis

作　　者：姚倩楠 贾金星 季健 黄新淋 程劭晨 李雨桐 孙洪言 Yao Qiannan;Jia Jinxing;Ji Jian;Huang Xinlin;Cheng Shaochen;Li Yutong;Sun Hongyan(School of Clinical Medicine,Jiamusi University,Jiamusi 154007,China;Imaging Department,Suzhou Guangji Hospital,Suzhou 215137,China)

机构地区：[1]佳木斯大学临床医学院,154007 [2]苏州市广济医院影像科,215137

出　　处：《神经疾病与精神卫生》2024年第10期698-706,共9页Journal of Neuroscience and Mental Health

基　　金：苏州市心境障碍临床医学中心项目(Szlcyxzx202109)。

摘　　要：目的基于独立成分分析(ICA),对比处于静息状态的青少年抑郁症患者与健康对照组的默认模式网络(DMN)及情感调控网络(AN)的差异。方法选取2022年10月—2023年7月苏州市广济医院门诊和住院收治的47例青少年抑郁症患者为青少年抑郁症组,同期选取性别、年龄、学历相匹配的35名健康对照者为健康对照组。对两组受试者进行静息态功能磁共振(rs-fMRI)扫描,采用ICA法分别提取两组受试者的DMN和AN,比较两组的网络内差异;采用Pearson相关分析青少年抑郁症患者差异脑区与患者健康问卷(PHQ-9)评分和病程的相关性。结果与健康对照组相比,青少年抑郁症组DMN中的左侧额上回、左侧角回、左侧后扣带回、左侧顶下小叶、右侧颞上回显著激活;AN中的左侧前扣带回、左侧颞极颞上回、左侧楔前叶、右侧脑岛激活(FWE校正,P<0.05,体素大小>25)。青少年抑郁症组左侧前扣带回与PHQ-9评分呈正相关(r=0.327,P=0.025),左侧楔前叶与患者病程呈正相关(r=0.394,P=0.006),右侧颞上回与患者病程呈正相关(r=0.297,P=0.043)。结论青少年抑郁症患者存在静息态下DMN和AN中脑区的异常激活,并且部分脑区与量表评分及病程存在显著相关性,提示其可能与青少年抑郁症情绪加工、记忆处理等认知功能变化相关。Objective To compare the differences in default mode network(DMN)and affective network(AN)between adolescents with depressive disorder and a healthy control group in a resting state based on independent component analysis(ICA).Methods From October 2022 to July 2023,47 adolescents with depressive disorder admitted to the outpatient and inpatient departments of Suzhou Guangji Hospital were selected as adolescent depression group,while 35 healthy controls matched for gender,age,and education were selected as the healthy control group during the same period.Two groups of subjects underwent resting state functional magnetic resonance imaging(rs-fMRI)scans.ICA was used to extract the DMN and AN of two groups of subjects,compare the intra network differences between the two groups.Pearson correlation was used to analyze the correlation between differential brain regions and Patient Health Questionnaire-9(PHQ-9)score and disease course in adolescents with depressive disorder.Results Compared with healthy control group,the left superior frontal gyrus,left angular gyrus,left posterior cingulate gyrus,left inferior parietal lobule,and right superior temporal gyrus were significantly activated in DMN of adolescent depression group,and the left anterior cingulate gyrus,left temporal pole superior temporal gyrus,left anterior cingulate cortex,and right insula in AN were significantly activated(FWE correction,P<0.05,voxel size>25).The left anterior cingulate gyrus in the adolescent depression group was positively correlated with PHQ-9 score(r=0.327,P=0.025),the left anterior cingulate gyrus was positively correlated with the patient's disease course(r=0.394,P=0.006),and the right superior temporal gyrus was positively correlated with the patient's disease course(r=0.297,P=0.043),with statistically significant differences.Conclusions Adolescents with depressive disorder exhibit abnormal activation of DMN and AN brain regions in a resting state,and some brain regions are significantly correlated with scale scores and disease cour

关 键 词：青少年 抑郁症 静息态功能磁共振 独立成分分析 默认网络 情感调控网络 

分 类 号：R749.4[医药卫生—神经病学与精神病学]