胃癌组织中SDF-1、HER2及Slug表达与患者临床病理特征的相关性  

The Correlation Between the Expression of SDF-1,HER2,and Slug in Gastric Cancer Tissue and the Clinical and Pathological Characteristics of Patients

作　　者：陈林林[1] 王花花[1] 李治国[1] 张远英 张萌萌 柳淼 闫勇 CHEN Linlin;WANG Huahua;LI Zhiguo(Jiaozuo People's Hospital,Jiaozuo,454000)

机构地区：[1]河南省焦作市人民医院,454000

出　　处：《实用癌症杂志》2024年第11期1789-1791,共3页The Practical Journal of Cancer

摘　　要：目的分析基质细胞衍生因子1(SDF-1)、人表皮生长因子受体2(HER2)、锌指转录因子(Slug)在胃癌组织内的表达及与患者临床病理特征间的关系。方法选取73例胃癌患者,采集其癌组织与癌旁正常组织,以免疫组织化学法检测对比两者SDF-1、HER2及Slug的表达差异;另收集患者的年龄等资料,统计分析SDF-1、HER2及Slug表达与胃癌患者各项临床病理特征间的联系。结果癌组织的SDF-1、HER2、Slug阳性表达率高于癌旁正常组织,差异有统计学意义(P<0.05)。SDF-1、HER2、Slug阳性表达与胃癌患者的年龄、性别无关(P>0.05),与患者的临床分期、淋巴结转移、分化程度有关(P<0.05)。结论SDF-1、HER2、Slug在胃癌组织内呈异常高表达,且其参与胃癌的侵袭、发展过程。Objective To analyze the expression of stromal cell derived factor 1(SDF-1),human epidermal growth factor receptor 2(HER2),and zinc finger transcription factor(Slug)in gastric cancer tissue and their relationship with clinical and pathological characteristics of patients.Methods 73 gastric cancer patients were selected,and their cancerous tissue and adjacent normal tissue were collected.The expression differences of SDF-1,HER2,and Slug between the 2 were detected and compared using immunohistochemistry;Collect age and other data of patients,and statistically analyze the relationship between the expression of SDF-1,HER2,and Slug and various clinical and pathological characteristics of gastric cancer patients.Results The positive expression rates of SDF-1,HER2,and Slug in cancer tissues were higher than those in adjacent normal tissues,with statistical significance(P<0.05).The positive expression of SDF-1,HER2,and Slug was not related to the age and gender of gastric cancer patients(P>0.05),but was related to the clinical stage,lymph node metastasis,and differentiation degree of patients(P<0.05).Conclusion SDF-1,HER2,and Slug are abnormally highly expressed in gastric cancer tissue,and they are involved in the invasion and development of gastric cancer.

关 键 词：胃癌 基质细胞衍生因子1 人表皮生长因子受体2 锌指转录因子 病理特征 

分 类 号：R735.2[医药卫生—肿瘤]