六君子汤加减对脾虚型晚期大肠癌的临床疗效及预后研究  

Clinical Efficacy and Prognosis of the Addition and Subtraction of Liu Jun Zi Tang on Advanced Colorectal Cancer of Spleen Deficiency Type

作　　者：彭玲珍 楚瑞阁[1] 徐婷[1] 王国娟[1] 张峰浩 陈颖 PENG Lingzhen;CHU Ruige;XU Ting(The Affiliated Hospital of Jiangxi University of TCM,Nanchang,330006)

机构地区：[1]江西中医药大学附属医院,330006 [2]江西省肿瘤医院,330029

出　　处：《实用癌症杂志》2024年第11期1827-1832,共6页The Practical Journal of Cancer

基　　金：江西省中医药科技计划(编号:2022B343)。

摘　　要：目的评估六君子汤加减联合化疗治疗脾虚型晚期大肠癌的临床疗效,并探寻其预后的相关影响因素。方法共收集整理脾虚型晚期(Ⅳ期)大肠癌患者完整资料73例,分为西医治疗组33例和中西医结合治疗组40例。西医治疗组行单纯化疗(或化疗联合靶向治疗),中西医结合治疗组在化疗(或化疗联合靶向治疗)的同时口服六君子汤加减中药汤剂。治疗前后进行KPS评分,比较两组患者的总生存期,采用寿命表法统计描述两组患者的3、6、9、12个月生存率,使用Kaplan-Meier法估算两组患者中位生存时间,使用单因素分析和Cox多因素回归模型分析影响脾虚型晚期肠癌患者的预后因素。结果治疗后两组KPS评分分布差异有统计学意义(P<0.001),中西医结合治疗组KPS评分明显高于西医治疗组。西医治疗组、中西医结合治疗组患者中位总生存期分别为10.1、14.5个月,差异具有统计学意义(P<0.001)。单因素分析筛选与Cox多因素分析表明:治疗方式、年龄、病理分化程度、合并其他基础疾病为预后相关的因素,其中独立影响因素是年龄、治疗方式以及合并其他基础疾病,中药联合化疗是影响患者预后的保护因素,年龄60~70岁以及合并有其他基础疾病是预后的危险因素。结论六君子汤加减联合化疗可延长脾虚型晚期肠癌患者总生存期,改善生活质量,是改善患者预后的保护性因素,患者年龄60~70岁、合并其他基础疾病是预后的危险因素。Objective To assess the clinical efficacy of the addition and subtraction of Liu Jun Zi Tang combined with chemotherapy in the treatment of advanced colorectal cancer of spleen deficiency type,and to explore the relevant influencing factors of its prognosis.Methods A total of 73 cases of advanced colorectal cancer patients with spleen deficiency(stageⅣ)were collected and organized into 33 cases in the western medicine treatment group and 40 cases in the combination of Chinese and western medicine treatment group.The western medicine treatment group was treated with simple chemotherapy(or chemotherapy combined with targeted therapy),and the combination of traditional Chinese and western medicine treatment group was treated with chemotherapy(or chemotherapy combined with targeted therapy)along with oral administration of Six Gentlemen's Tonic plus or minus traditional Chinese medicine soup.KPS scores were performed before and after treatment to compare the overall survival of patients in the 2 groups,the life table method was used to statistically describe the 3,6,9,and 12 month survival rates of patients in the 2 groups,the Kaplan-Meier method was used to estimate the median survival time of patients in the 2 groups,and the prognostic factors affecting patients with advanced intestinal cancers of the spleen-deficient type were analyzed using univariate analysis and Cox's multifactorial regression model.Results The difference in the distribution of KPS scores between the 2 groups after treatment was statistically significant(P<0.001),and the KPS scores in the combined Chinese and Western medicine treatment group were significantly higher than those in the Western medicine treatment group.The median overall survival of patients in the Western medicine treatment group and the combined Chinese and Western medicine treatment group was 10.1 months and 14.5 months,respectively,and the difference was statistically significant(P<0.001).Univariate analysis screening and Cox multifactorial analysis showed that treatment mo

关 键 词：脾虚型晚期肠癌 六君子汤 化疗 预后 

分 类 号：R735.34[医药卫生—肿瘤]