NSCLC患者放疗前后血清NSE、CA199、CEA、CA125水平及其与放疗疗效的关系  

Serum NSE,CA199,CEA and CA125 Levels in Patients with NSCLC Before and After Radiotherapy and Their Relationship with the Efficacy of Radiotherapy

作　　者：王平[1] 范姝婷 刘奕 张湘鲁[1] WANG Ping;FAN Shuting;LIU Yi(The Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第五附属医院,450000

出　　处：《实用癌症杂志》2024年第11期1881-1883,1887,共4页The Practical Journal of Cancer

摘　　要：目的非小细胞肺癌(NSCLC)患者放疗前后神经元特异性烯醇化酶(NSE)、糖类抗原199(CA199)、血清癌胚抗原(CEA)、CA125水平变化及其与放疗疗效的关系。方法选择接受放化疗的85例NSCLC患者,所有符合纳入标准的患者均实施1个月的放疗,根据实体瘤疗效评价标准(RECIST)将其分为有效组与无效组,比较放疗前后有效组与无效组的NSE、CA199、CEA、CA125水平变化。结果放疗前两组NSE、CA199、CEA、CA125水平相比,差异无统计学意义(P>0.05),放疗1个月后,有效组NSE、CA199、CEA、CA125水平均低于无效组(P<0.05),但无效组NSE、CA199、CEA、CA125水平均高于放疗前(P<0.05)。结论NSCLC患者放疗前后血清NSE、CA199、CEA、CA125水平均可发生显著变化,治疗有效者其NSE、CA199、CEA、CA125水平呈明显下降趋势,反之治疗无效者呈升高趋势,临床可根据上述指标预测其放化疗疗效的好坏,具有较好的应用前景。Objective To investigate the changes in neuron specific enolase(NSE),carbohydrate antigen 199(CA199),serum carcinoembryonic antigen(CEA)and CA125 levels in patients with non-small cell lung cancer(NSCLC)before and after radiotherapy,and their relationship with the efficacy of radiotherapy.Methods 85 patients with NSCLC who underwent radiotherapy were included in the study.All patients who met the inclusion criteria underwent 1 month of radiotherapy.They were divided into effective group and ineffective group according to the Response Evaluation Criteria In Solid Tumors(RECIST).The changes in NSE,CA199,CEA and CA125 levels before and after radiotherapy were compared between the effective group and the ineffective group.Results There was no statistically significant difference in NSE,CA199,CEA and CA125 levels between the 2 groups before radiotherapy(P>0.05).After a month of radiotherapy,NSE,CA199,CEA and CA125 levels in the effective group were lower than those in the ineffective group(P<0.05).NSE,CA199,CEA and CA125 levels in the ineffective group were higher than those before radiotherapy(P<0.05).Conclusion There are significant changes in serum NSE,CA199,CEA and CA125 levels in patients with NSCLC after radiotherapy.The levels show a significant decreasing trend in effectively treated patients,but an increasing trend in patients with treatment failure.The above indicators can help to predict the clinical efficacy of radiotherapy.

关 键 词：非小细胞肺癌 放疗前后 神经元特异性烯醇化酶 糖类抗原199 血清癌胚抗原 糖类抗原125 

分 类 号：R734.2[医药卫生—肿瘤]