^(125)I粒子植入联合经皮椎体成形术治疗脊柱转移癌对患者疼痛及脊髓神经功能的影响  

Effects of ^(125)I Implantation Combined with Percutaneous Vertebroplasty on Pain and Spinal Cord Nerve Function in Patients with Metastatic Spinal Cancer

作　　者：李志磊 张一 王建法 李亚威 王亚楠 孙国绍 LI Zhilei;ZHANG Yi;WANG Jianfa(Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou,462000)

机构地区：[1]郑州大学附属郑州中心医院,462000

出　　处：《实用癌症杂志》2024年第11期1888-1891,共4页The Practical Journal of Cancer

摘　　要：目的探讨^(125)I粒子植入+经皮椎体成形术治疗脊柱转移癌的临床疗效,及对患者疼痛、脊髓神经功能的影响。方法选用60例脊柱转移癌患者为研究对象,随机分为2组(观察组30例、对照组30例)。对照组给予开放手术治疗,观察组给予^(125)I粒子植入+经皮椎体成形术。比较2组治疗效果、疼痛情况、功能状态及脊髓神经功能。结果治疗后,与对照组总有效率70.00%比较,观察组93.33%明显提高(P<0.05)。治疗后2组疼痛情况均显著改善(P<0.05),且观察组VAS评分较对照组明显下降(P<0.05);2组功能状态均显著好转(P<0.05),且观察组KPS评分较对照组明显升高(P<0.05)。2组Frankel分级D、E级比例均较术前显著提高(P<0.05),但观察组与对照组比较,差异不明显(P>0.05)。结论^(125)I粒子植入和经皮椎体成形术治疗脊柱转移癌,效果较为理想,可有效缓解患者疼痛,改善功能状态,临床应用价值较高。Objective To investigate the clinical efficacy of ^(125)I implantation plus percutaneous vertebrae plasty in the treatment of spinal metastatic cancer,and the effect on pain and spinal nerve function.Methods 60 patients with spinal metastatic cancer were selected as the study objects and randomly divided into 2 groups(observation group,30 cases,control group,30 cases).The control group was given open surgery,and the observation group was given ^(125)I implantation+percutaneous vertebroplasty.The effect,pain,functional status and spinal nerve function of the 2 groups were compared after treatment.Results After treatment,the total effective rate in the observation group was increased by 93.33% compared with 70.00% in the control group(P<0.05).After treatment,the pain of both groups was significantly improved(P<0.05),and the VAS score of the observation group was significantly decreased compared with that of the control group(P<0.05);The functional status of the 2 groups was significantly improved(P<0.05),and the KPS score of the observation group was significantly higher than that of the control group(P<0.05).The proportions of Frankel grades D and E in the 2 groups were significantly higher than those before surgery(P<0.05),but there was no significant difference between the observation group and the control group(P>0.05).Conclusion The treatment of spinal metastatic cancer patients with ^(125)I particle implantation and percutaneous vertebroplasty is ideal,which can effectively alleviate pain and improve functional status,and has high clinical application value.

关 键 词：脊柱转移癌 ^(125)I粒子植入 经皮椎体成形术 疼痛 脊髓神经功能 

分 类 号：R730.5[医药卫生—肿瘤]