肾上腺皮质癌临床治疗研究进展  

Progress in clinical treatment of adrenal cortical cancer

作　　者：牛文静 梁华 牛立峰(综述) 张海梅(审校) Niu Wenjing;Liang Hua;Niu Lifeng;Zhang Haimei(School of Clinical Medicine,Shandong Second Medical University,Shandong Province,Weifang 261000,China;不详)

机构地区：[1]山东第二医科大学临床医学院,山东潍坊261000 [2]青岛市中心医院肿瘤科,山东青岛266000 [3]烟台市滨州医学院临床医学院,山东烟台264010

出　　处：《疑难病杂志》2024年第11期1399-1402,1408,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：“白求恩·精医求精-晚期实体瘤科研项目(二期)”研究课题(STLKY2-010)。

摘　　要：肾上腺皮质癌是一种预后不良的罕见恶性肿瘤,具有高度侵袭性。临床上以女性患者较为多见,该病形成的原因目前尚未阐明,可能与机体功能障碍、饮食、药物等因素有关,常表现为女性男性化及肾上腺功能亢进。由于肾上腺皮质癌侵袭性较强,容易发生转移,常见淋巴转移主要为肾上腺周围及大动脉周围淋巴结转移。故早期发现及手术完全切除是治疗该病的关键,尽可能切除肿瘤和相邻组织,从而提高治疗成功率。对于肿瘤远处转移、全身状况不佳等无法进行手术的肾上腺皮质癌患者,可考虑使用辅助疗法,如放疗、化疗、分子靶向治疗等,为患者争取较长的生存时间。文章对肾上腺皮质癌治疗的最新基础研究和临床研究进展进行综述,为肾上腺皮质癌临床治疗提供新的视角和经验。Adrenocortical carcinoma is a rare malignant tumor with poor prognosis and is highly aggressive.It is clinically more common in female patients.The cause of this disease has not yet been fully elucidated,but it may be related to organ dysfunction,dietary factors,and drug factors.It often manifests as virilization in females and hyperfunction of the adrenal glands.Due to the strong invasiveness of adrenocortical carcinoma and its propensity for metastasis,common lymphatic metastases mainly involve the lymph nodes around the adrenal glands and the large arteries.Therefore,early detection and complete surgical resection are key to treating the disease,with the aim of removing as much of the tumor and adjacent tissue as possible to increase the success rate of treatment.For patients with adrenocortical carcinoma who have distant metastases or poor general condition and are not candidates for surgery,adjunctive therapies such as radiotherapy,chemotherapy,and molecular targeted therapy may be considered to prolong survival.This article presents a comprehensive and systematic review of the latest basic and clinical research advances in the treatment of adrenocortical carcinoma.The aim is to provide new perspectives and experiences in the clinical treatment of adrenocortical carcinoma.

关 键 词：肾上腺皮质癌 临床治疗 研究进展 

分 类 号：R736.6[医药卫生—肿瘤]