桂林地区妇科患者HPV与常见性传播疾病病原体感染情况分析  

Analysis of HPV and common sexually transmitted disease pathogen infections in gynecological patients in Guilin Area

作　　者：文艳林 贝婷婷 范桂娟 林明[2] 刘姿 WEN Yanlin;BEI Tingting;FAN Guijuan;LIN Ming;LIU Zi(Department of Second Gynecology,Guilin Women's and Children's Hospital,Guilin,Guangxi Zhuang Autonomous Region 541001,China;不详)

机构地区：[1]桂林市妇女儿童医院妇二科,广西壮族自治区桂林541001 [2]广西壮族自治区妇幼保健院保健部

出　　处：《医学动物防制》2024年第10期1007-1010,1015,共5页Journal of Medical Pest Control

基　　金：广西自然科学基金面上项目(2020GXNSFAA019256);广西卫健委自筹经费科研项目(Z20210736)。

摘　　要：目的了解桂林地区妇科就诊患者人乳头瘤病毒(HPV)与解脲脲原体(Ureaplasma urealyticum,UU)、沙眼衣原体(Chlamydia trachomatis,CT)、淋病奈瑟菌(Neisseria gonorrhoeae,NG)等生殖道病原体混合感染状况及相关性,为进一步开展HPV防治提供理论依据。方法选择2021年1月—2022年12月桂林市某医院妇科门诊就诊的758例女性患者为研究对象,采集其宫颈分泌物及脱落宫颈细胞标本,采用全自动聚合酶链式反应(PCR)方法检测HPV-DNA,UU-DNA、CT-DNA和NG-DNA。根据HPV感染不同情况对患者进行分组,分析不同组别UU、CT、NG感染的差异,采用χ^(2)检验进行率的比较。结果患者生殖道HPV、UU、CT、NG的阳性检出率分别为20.18%、31.53%、14.38%、4.62%;高危型HPV阳性检出率为22.16%,主要基因亚型为HPV52、16、53、58和51型;HPV高危型组患者UU阳性检出率明显高于HPV低风险组和阴性组患者(χ^(2)=17.235,P<0.05);HPV高危型组患者的CT和NG阳性检出率高于HPV低风险组和阴性组患者,差异无统计学意义(χ^(2)=3.337、2.257,P>0.05);HPV低风险组与阴性组患者UU、CT和NG阳性检出率比较,差异无统计学意义(χ^(2)=0.127、0.061、0.671,P>0.05);感染两种及以上HPV亚型的患者UU、CT、NG阳性检出率明显高于单一感染患者(χ^(2)=4.543、7.586、5.371,P<0.05)。结论桂林地区妇科就诊患者的HPV感染率较高,以高危型为主,同时HPV感染与UU、CT、NG等病原体感染密切相关。建议对HPV阳性患者进行UU、CT、NG等病原体的联合检测。Objective To understand the mixed infection status and correlation between human papillomavirus(HPV)and reproductive tract pathogens such as Ureaplasma urealyticum(UU),Chlamydia trachomatis(CT),and Neisseria gonorrhoeae(NG)among patients attending gynecology clinics in Guilin Area,and to provide a theoretical basis for further prevention and treatment of HPV.Methods A total of 758 female patients who attended the gynecological outpatient clinic of a hospital in Guilin from January 2021 to December 2022 were selected as the research subjects,and their specimens of cervical secretions and exfoliated cervical cells were collected.HPV-DNA,UU-DNA,CT-DNA,and NG-DNA were detected by automated polymerase chain reaction(PCR).The patients were grouped according to the different situations of HPV infection,the differences in UU,CT,and NG infections in different groups were analyzed,and the rates were compared using theχ^(2)test.Results The positive detection rates of HPV,UU,CT,and NG in the reproductive tract of the patients were 20.18%,31.53%,14.38%,and 4.62%,respectively.The positive detection rate of high-risk HPV was 22.16%,with the main gene subtypes being HPV types 52,16,53,58,and 51.The positive detection rates of UU in HPV high-risk group patients were significantly higher than those in HPV low-risk group and negative group patients(χ^(2)=17.235,P<0.05).The positive detection rates of CT and NG in HPV high-risk group patients were also higher than those in HPV low-risk group and negative group patients,but the difference was not statistically significant(χ^(2)=3.337,2.257,P>0.05).Comparison of the positive detection rates of UU,CT and NG between patients in the HPV low-risk group and the negative group showed no statistically significant difference(χ^(2)=0.127,0.061,0.671,P>0.05).The positive rates of UU,CT,and NG in patients infected with two or more HPV subtypes were significantly higher than those in single infected patients(χ^(2)=4.543,7.586,5.371,P<0.05).Conclusion The HPV infection rate among patients att

关 键 词：生殖道 人乳头瘤病毒 解脲脲原体 沙眼衣原体 淋病奈瑟菌 宫颈癌 分析 

分 类 号：R737.33[医药卫生—肿瘤]