腹腔镜与开腹子宫肌瘤剔除术在子宫肌瘤治疗中的应用效果对比分析  

Comparative Analysis of the Application Effect of Laparoscopic and Open Hysteromyomectomy in the Treatment of Hysteromyoma

作　　者：徐秦萍 龚利英 XU Qinping;GONG Liying(Department of Obstetrics and Gynecology,Qidong Maternal and Child Health Hospital,Qidong,Jiangsu,226200,China)

机构地区：[1]启东市妇幼保健院妇产科,江苏启东226200

出　　处：《中外医疗》2024年第29期91-95,共5页China & Foreign Medical Treatment

摘　　要：目的对比分析开腹和腹腔镜下子宫肌瘤切除的临床疗效和对患者的内分泌状况的影响。方法方便选择2021年12月—2023年12月启东市妇幼保健院妇产科收治的102例子宫肌瘤患者为研究对象,依据不同手术治疗方法分为两组,研究组(n=51)采用腹腔镜下子宫肌瘤切除术,对照组(n=51)采用开腹手术治疗。比较两组患者手术指标、内分泌指标水平、肌瘤复发情况、氧化应激指标水平、血清学创伤指标。结果研究组手术时间长于对照组,出血量低于对照组,肛门排气时间、下床活动时间、住院时间均明显短于对照组,差异有统计学意义(P均<0.05)。术前,两组患者内分泌指标比较,差异无统计学意义(P均>0.05);术后,研究组雌二醇水平高于对照组,卵泡刺激素、黄体生成素水平均低于对照组,差异有统计学意义(P均<0.05)。两组患者子宫肌瘤复发情况比较,差异无统计学意义(P>0.05)。术前,两组患者氧化应激指标水平比较,差异无统计学意义(P均>0.05);术后3 d、7 d,研究组活性氧、丙二醛、晚期氧化蛋白产物水平均低于对照组,差异有统计学意义(P均<0.05)。术前,两组患者血清学创伤指标比较,差异无统计学意义(P均>0.05);术后3 d、7 d,研究组肌红蛋白、血清蛋白缺血修饰人白蛋白水平低于对照组,总抗氧化能力水平高于对照组,差异有统计学意义(P均<0.05)。结论针对子宫肌瘤患者,腹腔镜子宫肌瘤剔除术的损伤较小,且术后恢复较快,对内分泌水平的影响较小,可显著减轻人体炎症因子反应及组织创伤。Objective To compare and analyze the clinical efficacy of open and laparoscopic myomectomy and its in⁃fluence on the endocrine status of patients.Methods A total of 102 patients with hysteromyoma admitted to the De⁃partment of Obstetrics and Gynecology in Qidong Maternal and Child Health Hospital from December 2021 to Decem⁃ber 2023 were conveniently selected as the study objects.They were divided into two groups according to different sur⁃gical treatment methods.The study group(n=51)received laparoscopic myomectomy and the control group(n=51)re⁃ceived open surgery.The surgery index,endocrine index,fibroid recurrence,oxidative stress index and serological trauma index were compared between the two groups.Results The operation time of the study group was longer than that of the control group,the blood loss was lower than that of the control group,and the anal exhaust time,getting out of bed time and hospitalization time were significantly shorter than that of the control group,the differences were sta⁃tistically significant(all P<0.05).Before operation,there was no significant difference in endocrine indexes between the two groups(all P>0.05);after operation,the estradiol level of the study group was higher than that of the control group,and the levels of follicle-stimulating hormone and luteinising hormone were lower than those of the control group,the differences were statistically significant(all P<0.05).There was no significant difference in the recurrence of hysteromyoma between two groups(P>0.05).Before operation,there was no statistically significant difference in the levels of oxidative stress between two groups(all P>0.05);at 3 days and 7 days after operation,the levels of reactive oxygen species,malondialdehyde and advanced oxidation protein products in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).Before operation,there was no signifi⁃cant difference in serological trauma indexes between the two groups(all P>0.05);

关 键 词：腹腔镜子宫肌瘤剔除术 开腹手术 子宫肌瘤 内分泌 

分 类 号：R737.33[医药卫生—肿瘤]