Ⅲ期非小细胞肺癌患者行调强放疗和立体定向体部放疗同步化疗的效果对比  

Comparison of Concurrent Chemotherapy between Intensity Modulated Radiotherapy and Stereotactic Body Radiotherapy in Patients with StageⅢNon-small Cell Lung Cancer

作　　者：史奎宗 唐世波 陈珍 SHI Kuizong;TANG Shibo;CHEN Zhen(Department of Imaging,Zibo Maternal and Child Health Hospital,Zibo 255000,Shandong,China)

机构地区：[1]淄博市妇幼保健院影像科,山东淄博255000

出　　处：《世界复合医学（中英文）》2024年第9期135-139,共5页World Journal of Complex Medicine

摘　　要：目的比较Ⅲ期非小细胞肺癌患者行调强放疗和立体定向体部放疗同步化疗的效果。方法选取2020年1月—2023年1月淄博市妇幼保健院收治的50例Ⅲ期非小细胞肺癌患者为研究对象,所有患者均开展化疗(吉西他滨+顺铂方案),按治疗方法不同分为两组,各25例。对照组实施立体定向体部放疗,观察组实施调强放疗。对比两组临床疗效、免疫功能指标、血清细胞因子。结果两组客观缓解率与疾病控制率对比,差异无统计学意义(P均>0.05)。治疗后,研究组的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均高于对照组,CD8+低于对照组,差异有统计学意义(P均<0.05)。治疗后,研究组的白细胞介素-2为(231.92±14.44)μg/L,白细胞介素-6为(131.25±9.87)μg/L,肿瘤坏死因子-α为(4.59±1.09)μg/L,均低于对照组的(278.03±15.35)μg/L、(173.97±10.91)μg/L、(5.21±1.05)μg/L,差异有统计学意义(t=10.940、14.519、2.048,P均<0.05)。结论Ⅲ期非小细胞肺癌患者在化疗基础上联合调强放疗或者立体定向体部放疗具有显著疗效,且调强放疗对患者免疫功能的影响更小,可以更好地改善血清细胞因子水平。Objective To compare the effects of intensity modulated radiotherapy and stereotactic body radiotherapy in patients with stageⅢnon-small cell lung cancer(NSCLC).Methods From January 2020 to January 2023,a total of 50 patients with stageⅢnon-small cell lung cancer admitted to Zibo Maternal and Child Health Hospital were selected as the research objects.After admission,all patients were treated with chemotherapy(gemcitabine+cisplatin regime).According to different treatment methods,they were divided into two groups,25 cases in each group.The control group was treated with stereotactic body radiotherapy,and the observation group was treated with intensity modulated radiotherapy.The clinical efficacy,immune function indexes,serum cytokines were compared between the two groups.Results There was no significant difference in objective remission rate and disease control rate between the two groups(both P>0.05).After treatment,CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in the study group were higher than those in the control group,CD8+was lower than control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of interleukin-2 was(231.92±14.44)μg/L,interleukin-6 was(131.25±9.87)μg/L,tumor necrosis factor-αwas(4.59±1.09)μg/L,which were lower than(278.03±15.35)μg/L,(173.97±10.91)μg/L and(5.21±1.05)μg/L in the control group,and the differences were statistically significant(t=10.940,14.519,2.048,all P<0.05).Conclusion In patients with stageⅢnon-small cell lung cancer,chemotherapy combined with intensity modulated radiotherapy or stereotactic body radiotherapy has a significant effect,and intensity modulated radiotherapy has less impact on the immune function of patients and can better improve the serum cytokine level.

关 键 词：期非小细胞肺癌 调强放疗 立体定向体部放疗 化疗 

分 类 号：R734.2[医药卫生—肿瘤]