局部晚期口腔癌采用不同治疗方式疗效对比分析  

Comparative Analysis of Therapeutic Effects of Different Treatment Methods for Locally Advanced Oral Cancer

作　　者：韩小琴 李小军 周俊年 李冬山 宗晓琴 Han Xiaoqin;Li Xiaojun;Zhou Junnian(Wuwei Tumor Hospital,Wuwei,Gansu,733000,China)

机构地区：[1]甘肃省武威肿瘤医院,甘肃武威733000

出　　处：《黑龙江医学》2024年第22期2706-2708,2712,共4页Heilongjiang Medical Journal

基　　金：甘肃省陇原青年英才项目;武威市2020年度第二批市列科技计划资助项目(ww2002050)。

摘　　要：目的:对比分析局部晚期口腔癌采用不同治疗方式的短期疗效。方法:选取2017年1月—2021年6月甘肃省武威肿瘤医院就诊的139例口腔癌患者作为研究对象。根据采用的不同治疗方式分为A组(手术+化疗)、B组(手术+常规放疗+化疗)、C组(手术+常规放疗)和D组(碳离子放疗+化疗);评价不同治疗方式下各组间近期疗效,并采用Kaplan-Meier、Log-rank检验计算和比较分析治疗后1年、2年生存率。结果:B组有效率高于A组,差异有统计学意义(P<0.05),其余各组间有效率比较,差异无统计学意义(P>0.05);B组1年和2年生存率均高于其他3组;与B组相比,A组、D组的生存率均下降,A组、C组、D组各组间生存率比较,差异无统计学意义(P>0.05)。结论:局部晚期口腔癌术后辅助性放化疗能有效提高术后生存率,碳离子联合化疗有望为拒绝手术及无法耐受手术患者提供新的治疗选择。Objective:To compare and analyze the short-term efficacy of different treatment methods for locally advanced oral cancer.Methods:139 patients with oral cancer treated from January 2017 to June 2021 were selected,and followed up.According to different treatment methods,four groups were divided,group A(surgery+chemotherapy),group B(surgery+conventional radiotherapy+chemotherapy),group C(surgery+conventional radiotherapy),and group D(carbon ion radiotherapy+chemotherapy).The short-term efficacy of each group under different treatment methods was evaluated,and the 1-year and 2-year survival rates after treatment were analyzed by Kaplan-Meier and Log-rank tests.Results:The effective rate of group B was higher than that of group A,the difference was statistically significant(P<0.05),and there was no statistically significant difference in the effective rate of other groups(P>0.05).1-year and 2-year survival rates of group B were higher than those of the other 3 groups.Compared with group B,the survival rate of group A and Group D decreased,and there was no statistical significance in the survival rate of group A,Group C and group D(P>0.05).Conclusion:Adjuvant radiotherapy and chemotherapy after local advanced oral cancer surgery can effectively improve the survival rate after surgery.Carbon ion radiotherapy combined chemotherapy is expected to provide new treatment options for patients who refuse surgery and cannot tolerate surgery.

关 键 词：口腔癌 治疗方式 疗效 对比分析 

分 类 号：R739.8[医药卫生—肿瘤]