滋养层细胞表面抗原2在肝细胞腺瘤和肝细胞肝癌的表达及意义  

Expression of Trophoblast Cell Surface Antigen 2 in Hepatocellular Adenoma and Hepatocellular Carcinoma

作　　者：耿文静 单立兵 李纳 吴又明 王金生 Geng Wenjing;Shan Libing;Li Na(Department of Pathology,Xiaolan Hospital,Nanfang Medical College,Zhongshan,Guangdong,528415,China)

机构地区：[1]南方医科大学附属小榄医院病理科,广东中山528415 [2]南方医科大学附属小榄医院急诊科,广东中山528415

出　　处：《黑龙江医学》2024年第21期2578-2580,2584,共4页Heilongjiang Medical Journal

基　　金：中山市医学科研项目(2020A020380)。

摘　　要：目的:探讨滋养层细胞表面抗原2(Trop2)在肝细胞腺瘤(HCA)和肝细胞肝癌(HCC)的表达及意义。方法:收集2018—2021年南方医科大学附属小榄医院病理科收治的59例HCC患者、4例HCA患者的手术切除标本。采用免疫组化方法检测HCA和HCC中Trop2的表达,并计数微血管密度(MVD)和胆管反应(DR)。结果:Trop2标记间质DR与肝细胞腺瘤相比,肝细胞肝癌的间质DR减少或缺失,CD34标记的MVD降低。Pearson相关分析结果显示,Trop2小DR与CD34 MVD呈正相关(r=0.488,P<0.001)。结论:Trop2在促进肿瘤的发生发展及转移中有一定的作用。Objective:To explore the expression of Trop2 in hepatocellular adenoma and hepatocellular carcinoma.Methods:The specimens of surgery,including 59 cases of hepatocellular carcinoma and 4 cases of hepatocellular adenoma,were collected from the Department of Pathology in Nanfang Medical College Xiaolan Hospital from 2018 to 2021.These specimens were used to detect the expression of Trop2 in tissues hepatocellular carcinoma and hepatocellular adenoma by immunohistochemistry.Microvascular density and ductular reaction were counted.Results:Compared with hepatocellular adenoma,mesenchymal ductular reaction was reduced or absent and CD34-labeled microvascular density was decreased.Pearson correlation analysis showed that Trop2-labeled small ductular reaction was positively correlated with CD34-labeled microvessel density(r=0.488,P<0.001).Conclusion:The expression of Trop2 plays a role in promoting the occurrence,development and metastasis of tumors.

关 键 词：滋养层细胞表面抗原2 肝细胞腺瘤 肝细胞肝癌 胆管反应 微血管密度 病理学 

分 类 号：R735.7[医药卫生—肿瘤]