Supramolecular metallopolymer for hypoxia-activated ruthenium complexes delivery and smart chemo-photodynamic therapy  

作　　者：Maomao He Zhiyuan Ma Zongwei Zhang Linhao Zhang Shengqi Zhang Ran Wang Xuefei Leng Yang Li Jiangli Fan Wen Sun Xiaojun Peng 

机构地区：[1]Key Laboratory of Fine Chemicals,Frontiers Science Center for Smart Materials Oriented Chemical Engineering,Dalian University of Technology,Dalian 116024,China [2]Ningbo Institute of Dalian University of Technology,Ningbo 315016,China [3]Liaoning Binhai Laboratory,Dalian 116023,China

出　　处：《Science China Chemistry》2024年第11期3875-3885,共11页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (22078046);the Fundamental Research Fundamental Funds for the Central Universities (DUT22LAB601);the Liaoning Binhai Laboratory (LB-2023-03);the China Postdoctoral Science Foundation (2023M740487);the Postdoctoral Fellowship Program of CPSF (GZC20230353)。

摘　　要：The Ru complexes have garnered a great deal of attention for antitumor phototherapy;however, achieving efficient cellular uptake and tumor-specific activation represents a major challenge. Herein, we synthesize a hypoxia-activated Ru complex(Ru ANM) and construct it into supramolecular polymers(Poly Ru ANM) through high binding affinity interaction. The amphiphilic supramolecular polymers possess self-assembly, resulting in the formation of diverse nanostructures exhibiting a range of morphologies by simply adjusting the host-guest ratio. As the polymer nanostructure size and morphology have been optimized, Poly Ru ANM prevents premature drug leakage and accumulates rapidly in the tumor cells. In the tumor hypoxia microenvironment, the polymer undergoes selective activation and disintegration, leading to the unlock of Ru complexes.Notably, the subsequent application of red light irradiation exacerbates the hypoxia and potentiates the liberation of the Ru complexes. This polymer design concept provides some novel insights into on-demand drug delivery and smart chemophotodynamic therapy.

关 键 词：photosensitive Ru complexes supramolecular metallopolymers host-guest interaction hypoxia-activation smart chemophotodynamic therapy 

分 类 号：R730.5[医药卫生—肿瘤] O641.4[医药卫生—临床医学]