急性脑梗死患者外周血hs-CRP、WBC、NEU、HCY表达及其临床意义  

Expression and clinical significance of hs-CRP,WBC,NEU,HCY in peripheral blood of patients with acute cerebral infarction

作　　者：张媛媛[1] 王亮 师逸墨 王会军 陈艳霜 ZHANG Yuanyuan;WANG Liang;SHI Yimo;WANG Huijun;CHEN Yanshuang(Department of Neurology,Baoding First Hospital,Baoding Hebei 071000,China)

机构地区：[1]保定市第一医院神经内科,河北保定071000 [2]保定市第一医院功能科,河北保定071000

出　　处：《中国急救复苏与灾害医学杂志》2024年第11期1455-1458,共4页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：保定市科技计划项目(编号:2141ZF051)。

摘　　要：目的 探究急性脑梗死(ACI)患者外周血超敏C反应蛋白(hs-CRP)、白细胞计数(WBC)、中性粒细胞(NEU)、同型半胱氨酸(HCY)表达及其临床意义。方法 选取2021年8月—2023年1月本院收治的120例ACI患者作为研究对象(ACI组),根据美国国立卫生研究院卒中量表(NIHSS)将ACI患者分为轻度组48例、中度组45例、重度组27例,根据患者6个月预后情况,分为预后良好组71例与预后不良组49例。同时选取同时期来我院体检的健康人员116例作为对照组,分别检测外周血hs-CRP、WBC、NEU、HCY水平,采用Spearman法分析ACI患者外周血hs-CRP、WBC、NEU、HCY水平与NIHSS评分的相关性;采用受试者工作特征(ROC)曲线分析外周血hs-CRP、WBC、NEU、HCY水平对ACI患者预后不良的预测价值。结果 与对照组比较,ACI组外周血hs-CRP、WBC、NEU、HCY水平显著升高(P<0.05)。轻度组、中度组、重度组外周血hs-CRP、WBC、NEU、HCY水平比较差异有统计学意义(P<0.05);且两两比较,差异均有统计学意义(P<0.05)ACI患者外周血hs-CRP、WBC、NEU、HCY水平与NIHSS评分呈正相关(r=0.583、0.600、0.457、0.585,P<0.05)。ACI预后不良组患者外周血hs-CRP、WBC、NEU、HCY水平显著高于预后良好组(P<0.05)。hs-CRP、WBC、NEU、HCY水平单独与联合预测ACI患者预后不良的曲线下面积(AUC)分别为0.770、0.811、0.851、0.633、0.934,联合预测价值高于单独预测(P<0.05)。结论 hs-CRP、WBC、NEU、HCY在ACI患者外周血水平升高,与患者病情发生发展、预后评估有关,可以作为ACI病情诊断、治疗及预后评估的标志物。Objective To investigate the expression and clinical significance of peripheral blood high sensitivity Creactive protein(hs-CRP),white blood cell count(WBC),neutrophils(NEU),and homocysteine(HCY) in patients with acute cerebral infarction(ACI).Methods From August 2021 to January 2023,120 ACI patients admitted to our hospital were regarded as the study subjects(ACI group),according to the National Institutes of Health Stroke Scale(NIHSS),ACI patients were divided into a mild group of 48 cases,a moderate group of 45 cases,and a severe group of 27 cases,according to the 6-month prognosis of the patient,they were separated into a good prognosis group of 71 cases and a poor prognosis group of 49 cases.Meantime,116 healthy individuals who came to our hospital for physical examination were collected as the control group,the levels of hs-CRP,WBC,NEU,and HCY in peripheral blood were detected,respectively,Spearman method was applied to analyze the correlation between the levels of hs-CRP,WBC,NEU,HCY in peripheral blood of ACI patients and NIHSS score;ROC curve was applied to analyze the predictive value of peripheral blood hs-CRP,WBC,NEU,and HCY levels for poor prognosis in ACI patients.Results Compared with the control group,the levels of hs-CRP,WBC,NEU,and HCY in the peripheral blood of the ACI group were obviously increased(P<0.05).There was a statistically obvious difference in the levels of hs-CRP,WBC,NEU,and HCY in the peripheral blood among the mild,moderate,and severe groups(P<0.05);There were significant differences in the levels of hs-CRP,WBC,NEU and HCY in peripheral blood among mild group,moderate group and severe group(P<0.05).The difference between the two groups was also statistically significant(P<0.05 The levels of hs-CRP,WBC,NEU,and HCY in peripheral blood of ACI patients were positively correlated with NIHSS score(r=0.583,0.600,0.457,0.585,P<0.05).The levels of hs-CRP,WBC,NEU,and HCY in the peripheral blood of patients with poor prognosis of ACI were obviously higher than those of patients with good prog

关 键 词：急性脑梗死 超敏C反应蛋白 白细胞计数 中性粒细胞 同型半胱氨酸 

分 类 号：R743.3[医药卫生—神经病学与精神病学]