丁苯酞联合高压氧舱治疗在治疗急性脑梗死中的临床观察  

Clinical observation of butylphthalide combined with hyperbaric oxygen chamber treatment in the treatment of acute cerebral infarction

作　　者：张重礼 秦鹏涛 安利锋 Zhang Chong-li;Qin Peng-tao;An Li-feng(Department of Neurology,Pingdingshan Medical District,The 989 Hospital of the Joint Service Support Force of Chinese People's Liberation Army,Pingdingshan 467000,Henan,China)

机构地区：[1]中国人民解放军联勤保障部队第989医院平顶山市医疗区神经内科,河南平顶山467000

出　　处：《四川生理科学杂志》2024年第11期2468-2470,2575,共4页

摘　　要：目的:观察丁苯酞联合高压氧舱在治疗急性脑梗死(ACI)中的临床效果。方法:选择我院ACI病人92例,按随机数字表法将所有病人分为单一组(n=46)和联合组(n=46)。单一组采用丁苯酞,联合组采用丁苯酞联合高压氧舱,对比两组治疗效果。结果:联合组总有效率95.65%(44/46)较单一组80.43%(37/46)高(P<0.05);治疗后与单一组比较,联合组白介素-6(IL-6)、单核细胞趋化因子-1(MCP-1)、超敏C反应蛋白(hs-CRP)、国立卫生研究院卒中量表(NIHSS)、改良Rankin量表(mRS)评分较低,脑血流量(CBF)、脑血流速度(CBFV)较高(P<0.05);2组不良反应对比无显著差异(P>0.05)。结论:丁苯酞联合高压氧舱治疗用于ACI患者中疗效显著,能改善卒中程度,增加脑血流量,且安全性较高。Objective:To observe the clinical efficacy of the combination of butylphthalein and hyperbaric oxygen chamber in the treatment of acute cerebral infarction(ACI).Methods:92 patients with ACI in our hospital were selected and randomly divided into a single group(n=46)and a combination group(n=46)using a random number table.Single group treated with butylphthalein,combined group treated with butylphthalein combined with hyperbaric oxygen chamber,and compared the therapeutic effects of the two groups.Results:The total effective rate of the combined group was 95.65%(44/46),which was higher than that of the single group(80.43%(37/46))(P<0.05);After treatment,compared with the single group,the combination group had lower scores for interleukin-6(IL-6),monocyte chemoattractant protein-1(MCP-1),high-sensitivity C-reactive protein(hs CRP),National Institutes of Health Stroke Scale(NIHSS),and modified Rankin Scale(mRS),and higher cerebral blood flow(CBF)and cerebral blood flow velocity(CBFV)(P<0.05);There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:The combination of butylphthalein and hyperbaric oxygen chamber therapy has significant therapeutic effects in patients with ACI,can improve stroke severity,increase cerebral blood flow,and has high safety.

关 键 词：急性脑梗死 丁苯酞 高压氧舱 炎症因子 脑循环动力学 

分 类 号：R743.3[医药卫生—神经病学与精神病学]