生长抑素+兰索拉唑治疗对上消化道出血患者凝血功能及血清胃泌素炎症因子的影响  

Effects of combined treatment with somatostatin and lansoprazole on coagulation function and serum gastrin and inflammatory factors in patients with upper gastrointestinal bleeding

作　　者：万林华 Wan Lin-hua(Department 1 of Nancheng People's Hospital,Fuzhou 344700,Jiangxi,China)

机构地区：[1]南城县人民医院内一科,江西抚州344700

出　　处：《四川生理科学杂志》2024年第11期2573-2575,共3页

摘　　要：目的:探究生长抑素+兰索拉唑治疗对上消化道出血(Upper gastrointestinal bleeding,UGIB)患者凝血功能及血清胃泌素、炎症因子的影响。方法:选取2019年1月至2023年12月在我院接受治疗的UGIB患者60例,随机分为对照组和研究组(n=30),分别采用静脉滴注兰索拉唑30 mg治疗以及采用生长抑素3 mg持续泵入+静脉滴注兰索拉唑30 mg治疗。治疗前及治疗后2 w采用全自动凝血分析仪检测患者纤维蛋白原(Fibrinogen,FIB)、活化部分凝血时间(Activated partial thromboplastin time,APTT)、凝血酶原时间(Prothrombin time,PT),以酶联免疫吸附法检测胃泌素(Gastrin,GAS)、胃动素(Motilin,MLT)及肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、白细胞介素-6(Interleukin-6,IL-6),以免疫荧光法检测超敏C反应蛋白(High-sensitivity C-reactive protein,hs-CRP),并比较治疗2 w后两组患者临床疗效和不良反应(如腹泻、腹痛、恶心等)发生情况。结果:治疗前两组患者凝血功能、胃肠激素及炎症因子水平比较差异无统计学意义(P>0.05),治疗2 w后与对照组相比,研究组FIB水平及临床总有效率显著高,APTT、PT时间及GAS、MLT、TNF-α、hs-CRP、IL-6水平显著低(P<0.05),但两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:生长抑素+兰索拉唑治疗UGIB对患者凝血功能、胃肠激素及炎症因子水平均有明显改善,且疗效显著,安全性较好。Objective:To explore the effect of somatostatin+lansoprazole treatment on coagulation function,serum gastrin,and inflammatory factors in patients with upper gastrointestinal bleeding(UGIB).Methods:A total of 60 patients with UGIB who were treated in our hospital from January 2019 to December 2023 were randomly divided into a control group and a study group(n=30),and were treated with intravenous infusion of lansoprazole 30 mg and continuous infusion of somatostatin 3 mg+intravenous infusion of lansoprazole 30 mg,respectively.Before and after 2 weeks of treatment,the levels of fibrinogen(FIB),activated partial thromboplastin time(APTT),and prothrombin time(PT)were measured using a fully automated coagulation analyzer.Enzyme-linked immunosorbent assay was used to detect gastrin(GAS),motilin(MLT),tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6).Immunofluorescence was used to detect high-sensitivity C-reactive protein(hs-CRP).The clinical efficacy and adverse reactions(such as diarrhea,abdominal pain,nausea,etc.)were compared between the two groups after 2 weeks of treatment.Results:There was no significant difference in the levels of coagulation function,gastrointestinal hormones,and inflammatory factors between the two groups before treatment(P>0.05).After 2 weeks of treatment,the FIB level and clinical total effective rate in the study group were significantly higher than those in the control group,while the APTT,PT time,GAS,MLT,TNF-α,hs-CRP,and IL-6 levels were significantly lower(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The treatment of UGIB with somatostatin and lansoprazole significantly improves the coagulation function,gastrointestinal hormones,and inflammatory factor levels in patients,with significant efficacy and good safety.

关 键 词：生长抑素 兰索拉唑 上消化道出血 

分 类 号：R573.2[医药卫生—消化系统]