奥曲肽联合奥美拉唑钠治疗急性胰腺炎对临床症状及血清AMY的影响  

Effects of octreotide combined with omeprazole sodium on clinical symptoms and serum AMY in acute pancreatitis

作　　者：岑秀锦 石天成 刘玲 Cen Xiu-jin;Shi Tian-cheng;Liu Ling(Department of General Surgery,Leping People's Hospital,Jingdezhen 333300,Jiangxi,China;Department of Pulmonary Medicine,Fifth People's Hospital of Jingdezhen City,Jingdezhen 333300,Jiangxi,China;Department of Stomatology,Leping Maternal and Child Health Hospital,Jingdezhen 333300,Jiangxi,China)

机构地区：[1]乐平市人民医院普外科,江西景德镇333300 [2]景德镇市第五人民医院肺五科,江西景德镇333300 [3]乐平市妇幼保健院口腔科,江西景德镇333300

出　　处：《四川生理科学杂志》2024年第11期2576-2578,共3页

摘　　要：目的:探究奥曲肽联合奥美拉唑钠治疗急性胰腺炎对临床症状及血清淀粉酶(Amylase,AMY)的影响。方法:选取2022年1月~2024年7月期间我院收治的66例急性胰腺炎患者作为研究对象,以抽签法随机分为对照组和观察组,各33例。对照组采用奥曲肽注射治疗,观察组在对照组的基础上联合奥美拉唑钠注射治疗,两组治疗均持续1 w。对两组患者的疗效、症状改善时间、AMY及脂肪酶(Lipase,LPS)水平进行比较,并统计不良反应的发生情况。结果:治疗后,观察组有效率明显高于对照组(P<0.05);观察组患者肠鸣音异常、腹痛、发热、腹胀等症状的改善时间明显短于对照组(P<0.05);两组血清AMY及LPS水平较治疗前均降低,且观察组明显低于对照组(P<0.05);两组不良反应发生率无明显差异(P>0.05)。结论:针对急性胰腺炎患者采用奥曲肽联合奥美拉唑钠注射治疗的方案,可有效提高患者的治疗效果,缩短其症状改善时间,改善其血清AMY及LPS水平,不良反应发生情况少,安全性高。Objective:To explore the effects of octreotide combined with omeprazole sodium on clinical symptoms and serum amylase(AMY)in acute pancreatitis.Methods:According to envelope method,66 patients with acute pancreatitis admitted to the hospital were randomly divided into control group(octreotide injection)and observation group(omeprazole sodium for injection on basis of control group)between January 2022 and July 2024,33 cases in each group.All were treated for 1 week.The curative effect,improvement time of symptoms,levels of serum AMY and lipase(LPS)in the two groups were compared,and the occurrence of adverse reactions was statistically analyzed.Results:After treatment,effective treatment rate of observation group was significantly higher than that of control group(96.97%vs 81.82%,P<0.05).The improvement time of symptoms(abnormal bowel sound,abdominal pain,fever,abdominal distension)in observation group was significantly shorter than that in control group(P<0.05).After treatment,levels of serum AMY and LPS were decreased in both groups,which were significantly lower in observation group(P<0.05).There was no significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion:Octreotide combined with omeprazole sodium injection can effectively improve curative effect,shorten improvement time of symptoms,reduce levels of serum AMY and LPS in patients with acute pancreatitis,which has few adverse reactions and high safety.

关 键 词：奥曲肽 奥美拉唑钠 奥曲肽联合奥美拉唑钠 血清淀粉酶 

分 类 号：R576[医药卫生—消化系统]