浓缩生长因子联合Bio-Oss骨粉在拔牙后牙槽嵴保存中的应用效果  

Treatment outcomes of concentrated growth factor plus Bio-Oss bone powder for alveolar ridge preservation after tooth extraction

作　　者：常颖[1] 赵宁 杨文朋 王维丽[1] CHANG Ying;ZHAO Ning;YANG Wen-peng;WANG Wei-li(Department of Stomatology,Aerospace Center Hospital Beijing 100049,China;Tianyin Dental Clinic,Beijing 100085,China)

机构地区：[1]航天中心医院口腔科,北京100049 [2]北京天尹口腔门诊部,北京100085

出　　处：《口腔颌面修复学杂志》2024年第6期428-433,467,共7页Chinese Journal of Prosthodontics

基　　金：海淀区卫生健康发展科研培育计划(项目编号:HP2022-12-507002)。

摘　　要：目的:观察浓缩生长因子(concentrated growth factor,CGF)联合Bio-Oss骨粉在拔牙后牙槽嵴保存(ARP)中的临床应用效果。方法:选择2022年1-6月于航天中心医院口腔科拔除单颗后牙的患者64例,按随机数字表法分为观察组和对照组,每组32例。观察组微创拔牙后联合植入CGF及Bio-Oss混合物并覆盖CGF膜缝合,对照组微创拔牙后直接缝合。术后14 d、28 d复诊观察软组织愈合情况。术前1周及术后6个月进行锥形束计算机体层摄影(CBCT),测量牙槽骨高度和宽度,比较数值变化,进行统计学分析。结果:因对照组2例未能按要求随访,最终入组62例。术后14 d观察组牙龈软组织愈合指数评分为5(4,6),低于对照组评分7(6,8),差异有统计学意义(P<0.05);术后28 d两组愈合指数均为4(4,4),差异无统计学意义(P>0.05)。术后6个月对照组牙槽骨高度和宽度分别为(8.05±1.83)mm和(6.11±1.72)mm,均低于术前(11.07±1.47)mm和(9.13±1.84)mm,差异有统计学意义(P<0.05)。观察组牙槽骨高度和宽度分别为(11.21±2.98)mm和(9.34±1.70)mm,与术前(11.75±2.54)mm和(9.45±1.60)mm比较,差异无统计学意义(P>0.05);术后两组间比较,观察组牙槽骨高度(11.21±2.98)mm和宽度(9.34±1.70)mm,均高于对照组牙槽骨高度(8.05±1.83)mm和宽度(6.11±1.72)mm,差异有统计学意义(P<0.05)。结论:在拔牙窝内联合植入CGF及Bio-Oss骨粉混合物并覆盖CGF膜行牙槽嵴保存治疗,可降低炎症反应,减少牙槽骨吸收,促进软硬组织形成。Objective:To observe the clinical outcomes of concentrated growth factor(CGF)plus Bio-Oss bone powder for alveolar ridge preservation(ARP)after tooth extraction.Methods:Sixty-four patients who underwent single posterior tooth extraction at the Department of Stomatology ofAerospace Center Hospital between January and June 2022 were selected and randomly divided into observation(n=32)and control(n=32)groups.The observation group underwent minimally invasive tooth extraction followed by implantation of a mixture of CGF and Bio-Oss bone powder.Suturing was then performed using a CGF membrane.The control group underwent minimally invasive tooth extraction followed by direct suturing.Soft tissue healing was observed during follow-up visits at 14 and 28 days postoperatively.Cone-beam computed tomography was performed 1 week before surgery and 6 months after surgery to determine alveolar bone height and width for comparison and statistical analysis.Results:Two patients in the control group were lost to follow-up.Therefore,62 patients were included in the final analysis.Fourteen days postoperatively,the gingival soft-tissue wound healing index score was significantly lower in the observation group[5(4,6)]than in the control group[7(6,8);P<0.05].Twenty-eight days postoperatively,both groups had a wound healing index score of 4(4,4),suggesting no significant difference between the two groups(P>0.05).Six months postoperatively,the alveolar bone height and width in the control group(8.05±1.83 mm and 6.11±1.72 mm,respectively)were significantly lower than the preoperative values(11.07±1.47 mm and 9.13±1.84 mm,respectively;P<0.05).In the observation group,the alveolar bone height andwidth(11.21±2.98 mmand 9.34±1.70 mm,respectively)did not significantly differ fromthe preoperative values(11.75±2.54 mmand 9.45±1.60 mm,respectively;P>0.05).After surgery,the observation group had significantly higher alveolar bone height(11.21±2.98 mm)and width(9.34±1.70 mm)than the control group(8.05±1.83 mm and 6.11±1.72 mm,respective

关 键 词：浓缩生长因子(CGF) 牙槽嵴保存(ARP) 微创 骨吸收 

分 类 号：R780.2[医药卫生—口腔医学]