复方血栓通联合维胺酯治疗口腔扁平苔藓合并慢性牙周炎的效果  

Effect of compound Xueshuantong combined with viaminate of oral lichen planus complicated with chronic periodontitis

作　　者：汪茂青 李文慧 蔡美煌[2] WANG Maoqing;LI Wenhui;CAI Meihuang(Department of Stomatology,the Second Affiliated Hospital of Chengdu Medical College,416 Hospital of Nuclear Industry,Chengdu 610051,Sichuan,China;不详)

机构地区：[1]成都医学院第二附属医院·核工业四一六医院口腔科,四川成都610051 [2]四川省中西医结合医院骨科,四川成都610041

出　　处：《实用医学杂志》2024年第21期3076-3081,共6页The Journal of Practical Medicine

基　　金：四川省中医药管理局科学技术研究专项课题(编号:2021MS328)。

摘　　要：目的 探讨复方血栓通联合维胺酯治疗口腔扁平苔藓(OLP)合并慢性牙周炎(CP)的临床疗效。方法 305例患者随机分为观察组156例和对照组149例。所有患者均进行牙周炎系统治疗,对照组采用维胺酯胶囊治疗,观察组采用复方血栓通胶囊联合维胺酯胶囊治疗。检测临床疗效、血清炎症因子[基质金属蛋白酶-3(MMP-3)、γ-干扰素(IFN-γ)、白细胞介素-6(IL-6)、IL-35]、口腔黏膜疼痛视觉模拟评分(VAS)、OLP病损面积、牙周情况、不良反应。结果 观察组总有效率高于对照组(P <0.05)。治疗后,两组血清MMP-3、IL-6水平、口腔黏膜VAS评分、OLP病损面积、牙龈指数、探诊深度均降低(P <0.05),以观察组更明显(P <0.05)。两组不良反应发生率比较差异无统计学意义(P> 0.05)。结论 复方血栓通联合维胺酯可有效改善OLP合并CP症状,减轻炎症反应,疗效良好。Objective To investigate the effect of compound Xueshuantong combined with viaminate of oral lichen planus(OLP) complicated with chronic periodontitis(CP).Methods This study collected 305 patients with OLP and CP and randomly divided them into two groups.There were 156 patients in the observation group and 149 patients in the control group.All patients receive systemic treatment for CP.The control group was treated with viaminate capsules,and the observation group was treated with compound Xueshuantong Capsules combined with viaminate capsules.Both groups were treated for 4 weeks.Clinical efficacy,serum inflammatory factors [matrix metalloproteinase-3(MMP-3),IFN-gamma(IFN-γ),interleukin 6(IL-6) and IL-35],oral mucosal pain Visual Analogue Score(VAS),lesion area of OLP,periodontal condition,and adverse reactions were detected.Results Compared to the control group,the total effective rate in the observation group was higher(P < 0.05).After treatment,serum MMP-3 and IL-6 levels,oral mucosal VAS score,lesion area of OLP,gingival index and probing depth all decreased in the two groups(P < 0.05).The changes of above indicators were more significant in the observation group(P < 0.05).There was no difference in the incidence of adverse reactions between the two groups(P > 0.05).Conclusion Compound Xueshuantong combined with viaminate can effectively improve the symptoms of OLP complicated with CP,and alleviate inflammatory reactions,with good therapeutic effects.

关 键 词：口腔扁平苔藓 牙周炎 复方血栓通胶囊 维胺酯胶囊 炎症反应 

分 类 号：R781.4[医药卫生—口腔医学] R781.5[医药卫生—临床医学]