妇科恶性肿瘤放化疗相关血小板减少症规范化管理中国专家共识(2024年版)  

Chinese expert consensus on standardized management of chemoradiotherapy related thrombocytopenia in gynecological malignant tumors(2024 Edition)

作　　者：中国医院协会妇产医院分会妇科肿瘤专业学组 中国抗癌协会中西整合卵巢癌专业委员会 芦恩婷 李芳梅[2] 邓雷 张颐[2] 王建东[3] 刘淑娟 张松灵[5] 天敏 王冬 王刚 张师前[9] Gynecologic Oncology Specialty Group of Obstetrics and Gynecology Hospital Branch of Chinese Hospital Association;China Anti-Cancer Association Chinese-Western Integrated Ovarian Cancer Committee

机构地区：[1]不详 [2]中国医科大学附属第一医院 [3]首都医科大学附属北京妇产医院 [4]空军军医大学第一附属医院/西京医院 [5]吉林大学白求恩第一医院 [6]吉林大学白求恩第二医院 [7]重庆大学附属肿瘤医院 [8]四川省妇幼保健院 [9]山东大学齐鲁医院

出　　处：《癌症进展》2024年第19期2089-2095,共7页Oncology Progress

基　　金：辽宁省应用基础研究计划项目(2022JH2/101300039);2022年沈阳市科技计划项目(22-321-33-08);沈阳市科技局2023年助力中国医科大学高质量发展专项(23-506-3-01-10)。

摘　　要：血小板减少症是妇科恶性肿瘤患者在放化疗过程中常见的不良反应之一,是临床需要密切关注的重点,其可导致化疗药物治疗剂量降低,规律治疗进程受阻,增加患者出血风险,对疾病产生严重影响,严重时可能导致患者死亡。为进一步优化临床用药实践,本共识基于坚实的循证证据,明确妇科恶性肿瘤放化疗相关血小板减少症的预防及治疗策略,并确立了相应的临床路径及合适的给药方式。同时,本共识评估了促血小板生成药物在妇科恶性肿瘤放化疗过程中应用的有效性及安全性,旨在形成妇科恶性肿瘤放化疗相关血小板减少症规范化管理的中国专家共识。Thrombocytopenia is one of the common adverse reactions in gynecological malignant tumor patients undergoing radiotherapy and chemotherapy,and it is the focus that clinicians need to pay close attention to.It can lead to the reduction of therapeutic dose,the obstruction of regular treatment process,the increase of bleeding risk of patients,and the serious impact of the disease,which can lead to death in severe cases.In order to further optimize clinical medication practice,this consensus,based on solid evidence-based evidence,defines prevention and treatment strategies for chemoradiationrelated thrombocytopenia in gynecological malignant tumors,and establishes corresponding clinical pathways and appropriate administration modalities.At the same time,this consensus evaluates the effectiveness and safety of the application of thrombopoietic drugs in the course of chemoradiotherapy for gynecological malignant tumors,and aims to form a Chinese expert consensus on the standardized management of chemoradiotherapy-related thrombocytopenia for gyneco-logical malignant tumors.

关 键 词：妇科恶性肿瘤 放化疗 血小板减少症 专家共识 

分 类 号：R737.3[医药卫生—肿瘤]